摘要
目的 :优化淫羊藿黄酮磷脂复合物 (EFL)的制备工艺 ,研究其适配剂型 ,建立质量评价方法。方法 :采用均匀设计逐步回归优化复合物制备工艺 ;以溶剂挥发法制备EFL与聚乙烯吡咯烷酮 (PVP)的共沉淀物 ;以体外溶出度法考察不同配比PVP共聚物胶囊的药物累积溶出度。结果 :EFL的优化制备条件为 :四氢呋喃作溶剂 ,卵磷脂为药物的 2 .5倍 ,40℃搅拌 3h ,EFL中淫羊藿苷的油 /水表观分配系数平均提高 4倍 ;EFL PVP(1∶3)共沉淀物胶囊的累积溶出度明显高于物理混合物及心神宁片。结论 :磷脂可提高淫羊藿黄酮中淫羊藿苷的油 /水表观分配系数 ,EFL PVP(1∶3)共沉淀物可提高EFL的体外溶出 ;而EFL的体内过程有待进一步研究。
Objective: To optimize preparation techniques for Herba Epimedii flavonoid phytosomes (EFP) and explore their suitable pharmaceutics. Methods: To optimize the preparation conditions by means of uniform design and step regression, prepare Herba Epimedii total flavonoid phytosomes by means of solvent evaporation and investigate the accumulative dissolution of different ratios of EFP PVP precipitates by means of dissolution release. Result: The optimized preparation conditions are as follows: solvent tetrahydrofuran, lecithin to PVP 2.5 times, temperature 40 ℃ and reaction 3 hours. Oil/water apparent partition coefficient of icariin was enhanced more than 4 times by phospholipid. The accumulative dissolution of Herba Epimedii flavonoids of EFP PVP precipitate was significantly higher than that of its physical mixture and Herba Epimedii extract tablet. Conclusion: Phospholipid can effectively enhance the oil/water apparent partition coefficient of icariin, and PVP can improve the dissolution of Herba Epimedii phytocomes, but the pharmacokinetics needs further study. [
出处
《中国中药杂志》
CAS
CSCD
北大核心
2001年第2期105-108,共4页
China Journal of Chinese Materia Medica
关键词
淫羊藿黄酮
磷酯复合物
均匀设计
制备
剂型
Herba epidedii flavonoid phospholipid
uniform design
oil/water apparent partition coefficient
PVP precipitate
capsule
accumulative dissolution.
