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Nrf2-Keap1信号通路与脑卒中 被引量：2

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摘要 脑卒中已成为世界上导致死亡和神经功能障碍的主要原因，严重危害人类健康。目前认为，缺血性脑组织损伤是由多种因素参与的复杂病理过程，其发病机制涉及脑组织能量代谢紊乱、兴奋性氨基酸中毒、氧化应激损伤、炎症反应等多个环节。目前最主要的治疗措施是溶栓血运重建，
作者 张宇 张兵
机构地区 哈尔滨医科大学附属第二医院麻醉科
出处 《中风与神经疾病杂志》 CAS CSCD 北大核心 2014年第4期372-374,共3页 Journal of Apoplexy and Nervous Diseases
基金 国家自然科学基金(No.81372026 81000822)
关键词 脑卒中 信号通路 脑组织损伤 神经功能障碍 能量代谢紊乱 氧化应激损伤 人类健康 病理过程
分类号 R743.3 [医药卫生—神经病学与精神病学]
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参考文献25

  • 1Moi P,Chan K,Asunis I,et al.Isolation of NF-E2-related factors 2 (Nrf2),a NF-E2-1ike basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control regions[J].Proc Natl Acad Sci USA,1994,91 (21):9926-9930.
  • 2Takagi Y,Kobayashi M,Li L,et al.MatT,a new member of the small Maf protein family in zebrafish [J].Biochem Biophys Res Commun,2004,320(1):62-69.
  • 3Nioi P,Nguyen T,Sherratt PJ,et al.The earboxy-termainal Neh3 do-main of Nrf2 is required for transcriptional activation [J].Mol Cell Bi-ol,2005,25(24):10895-10906.
  • 4Uruno A,Motohashi H.The Keapl-Nrf2 system as an in vivo sensor for electrophiles [J].Nitric Oxide,2011,25 (2):153-160.
  • 5Kang MI,Kobayashi A,Wakabayashi N,et al.Scaffolding of Keapt to the actin cytoskeleton controls the function of Nrf2 as key regulator of eytoproteetive phase 2 genes [J].Proc Natl Aead Sci USA,2004,101 (7):2046-2051.
  • 6Kansanen E,Kuosmanen SM,Leinonen H,et al.The Keapl-Nrf2 pathway:Mechanisms of activation and dysregulation in cancer[J].Redox Biol,2013,18(1):45-49.
  • 7Taquchi K,Motohashi H,Yamamoto M.Molecular mechanisms of the Keapl-Nrt2 pathway in stress response and cancer evolution [J].Genes Cells,2011,16 (2):123-140.
  • 8Yang C,Zhang X,Fan H,et al.Curcumin upregulates transcription factor Nrf2,HO-1 expression and protects rat brains against focal is-chemia[J].Brain Res,2009,1282:133-141.
  • 9Tanaka N,Ikeda Y,Ohta Y,et al.Expression of Keapl-Nrf2 system and antioxidative proteins in mouse brain after transient middle cere-bral artery occlusion [J].Brain Res,2011,1370:246-253.
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二级参考文献13

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  • 6Heiss WD, Graf R, Wienhard K, et al. Dynamic penumbra demonstrated by sequential multitracer PET after middle cerebral artery occlusion in cats [J]. J Cereb Blood Flow Metab,1994,14 (6) :892- 902.
  • 7Ramos-Gomez M, Dolan PM, Itoh K, et al Interactive effects of nrf2 genotype and ohipraz on benzo[ a ] pyrene-DNA adducts and tumor yield in mice [J]. Carcinogenesis,2003,24 (3) :461-467.
  • 8Innamorato NG, Rojo AI, Garcia-Yague A J, et al. The transcription factor Nrf2 is a therapeutic target against brain inflammation [ J ]. J Immunol,2008,181 ( 1 ) :680-689.
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  • 10Yang Y, Li Q, Shuaib A. Neuroprotection by 2-h postischemia administration of two free radical scavengers, alpha-phenyl-n-tert-butyl-nitrone ( PBN ) and N-tert-butyl-( 2-sulfophenyl ) -nitrone ( S- PBN) ,in rats subjected to focal embolic cerebral ischemia [ J]. Exp Neurol,2000,163 ( 1 ) :3945.

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中风与神经疾病杂志
2014年 第4期

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