摘要
目的:观察大鼠肛门水肿组织病理改变和广痛消泡沫气雾剂的干预作用。方法:SD大鼠用0.16 mL巴豆油混合液致肛门肿胀,治疗组肛门内给予广痛消泡沫气雾剂,分别于给药后24 h、48 h、72 h全部处死,取肛周组织进行染色处理,显微观察空白组、模型组、治疗组及对照组病理改变。结果:空白组直肠黏膜正常;模型组直肠黏膜呈急性炎症改变;治疗组随着给药天数的增加,黏膜层溃疡逐渐好转,黏膜下层充血、水肿明显改善,血管充血、扩张消失,对照组炎症改变不明显。结论:巴豆油注射可致SD大鼠肛门水肿炎性改变;广痛消泡沫气雾剂对大鼠肛门肿胀具有抗炎、消肿的作用。
Objective To observe the pathological changes of edema in rat anus and the intervention ef-fects of Guangtongxiao （广痛消）foam aerosol. Methods SD rats were induced swelling of the anus by 0.16 mL croton mixture oil. The treatment group were given Guangtongxiao （广痛消）foam aerosols into the anus. All were killed after administration In the first three days respectively, taking perianal tissue staining pro-cess and microscopic pathologic changes observed in the blank group, model group, treatment group and the con-trol group. Results The rectal mucosa of the blank group was normal, of which the model group showed in acute inflammation. With increasing of drug delivery days, the ulcer of mucosa in the treatment group gradually improved, hyperemia and edema of the submucosa showed better, with less expansion of vascular congestion. The inflammatory changes of the control group were not obvious. Conclusion Croton oil injection can cause edema and inflammatory changes in SD rat anus; Guangtongxiao（广痛消）foam aerosol can lead to anti-inflam-matory and antioncotic to anal swelling of rats .
出处
《中国中西医结合外科杂志》
CAS
2014年第2期163-166,共4页
Chinese Journal of Surgery of Integrated Traditional and Western Medicine
关键词
广痛消泡沫气雾剂
巴豆油
大鼠水肿
病理改变
Guangtongxiao（广痛消）foam aerosol
croton oil
anal edema in rats
pathological changes
