期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

Six1蛋白在恶性肿瘤中的研究进展 被引量：11

暂未订购
导出
摘要 Six1是同源盒基因家族中的成员,与胚胎细胞发育和器官分化有关,促进细胞分化前的前体细胞增殖和生存。Cyclin D1、Cyclin A1和c-myc在细胞生长和增殖中起着至关重要的作用,Six1通过这些蛋白可调控细胞周期。文献报道,Six1通过组织、血液系统及阶段依赖等多种方式调节癌细胞启动、增殖和转移,在肿瘤发生、发展中发挥重要作用。该文总结Six1蛋白在恶性肿瘤发生、发展中的作用及其分子机制研究进展,Six1有可能成为抑制肿瘤生长的靶点。
作者 金爱花 金海燕
机构地区 延边大学附属医院消化内科
出处 《临床与实验病理学杂志》 CAS CSCD 北大核心 2014年第4期437-440,共4页 Chinese Journal of Clinical and Experimental Pathology
关键词 恶性肿瘤 Six1 相关性 文献综述
分类号 R730 [医药卫生—肿瘤]
  • 相关文献

参考文献2

二级参考文献25

  • 1Fletcher C D M,Unni K K,Mertens F.World Health Organization classification of tumors.Pathology & genetics tumors of soft tissue and bone[M].Lyon:IARC Press,2002:290-304.
  • 2Kim M S,Song W S,Cho W H,et al.Ezrin expression predicts survival in stage ⅡB osteosarcomas[J].Clin Orthop Relat Res,2007,459(7):229-36.
  • 3Jemal A,Siegel R,Ward E,et al.Caner statistics,2006[J].CA Cancer J Clin,2006,56(2):106-30.
  • 4Unni K K.Dahlin's Bone Tumor,general aspects and data on 11087 cases[M].5th ed.Philadephia:Lippincott Williams & Wilkins,1996:97-105.
  • 5Kalil R K,Inwards C Y,Unni K K,et al.Dedifferentiated clear cell,chondrosarcoma[J].Am J Surg Pathol,2000,24(8):1079-86.
  • 6Zhang Y,Hu M Y,Wu W Z,et al.The membrane-eytoskeleton organizer Ezrin is necessary for hepatocellular carcinoma cell growth and invasiveness[J].J Cancer Res Clin Oncol,2006,132(11):685-97.
  • 7Vaheri A,Carpen O,Heiska L,et al.The ezrin protein family:Membrane-cytoskeleton intevactions and disease associations[J].Curr Opin Cell Biol,1997,9(5):659-66.
  • 8Moilanen J,Lassus H,Leminen A,et al.Ezrin immunoreactivity in relation to survival in serous ovarian carcinoma patients[J].Gynecol Oncol,2003,90(2):273-81.
  • 9Song J,Fadiel A,Edusa V,et al.Estradiol-induced ezrin over expression in ovarian cancer:a new signaling domain for estrogen[J].Cancer Lett,2005,220(1):57-65.
  • 10S(o)derstr(o)m M,Palokangas T,Vahlberg T,et al.Expression of ezrin,Bcl-2,and Ki-67 in chondrosarcomas[J].APMIS,2010,118(10):769-76.

共引文献9

同被引文献71

  • 1陈玮,赵涌.MCM5和Ki67在宫颈上皮内瘤变及宫颈癌组织中表达及意义[J].第三军医大学学报,2007,29(14):1436-1439. 被引量：11
  • 2Christensen KL, Brennan JD, Aldridge CS, et al. Cell cycle regulation of the human Sixl homeoprotein is mediated by APC ( Cdhl ) [ J ]. Oncogene, 2007, 26 (23) : 3406 - 3414.
  • 3Pearson JC, Lemons D, McGinnis W. Modulating Hox gene functions during animal body patterning [ J ]. Nat Rev Genet, 2005, 6 ( 12 ) : 893 - 904.
  • 4Kumar JP. The sineoculis homeobox (SIX) family of transcription factors as regulators of development and disease [ J ]. Cell Mol Life Sci, 2009, 66(4) : 565 -583.
  • 5Wu W, Huang R, Wu Q, et al. The role of Sixl in the genesis of muscle cell and skeletal muscle development [ J ]. Int J Biol Sci, 2014, 10(9) : 983 -989.
  • 6Behbakht K, Qamar L, Aldridge CS, et al. Six1 overexpression in ovarian carcinoma causes resistance to TRAIL-mediated apoptosis and is associated with poor survival [ J ]. Cancer Res, 2007, 67 (7) : 3036 - 3042.
  • 7Ng KT, Man K, Sun CK, et al. Clinicopathological significance of homeoprotein Sixl in hepatocellular carcinoma[ J]. Br J Cancer, 2006, 95(8) : 1050-1055.
  • 8Wan F, Miao X, Quraishi I, et al. Gene expression changes during HPV-mediated carcinogenesis: a comparison between an in vitro cell model and cervical cancer [ J ]. Int J Cancer, 2008, 123 ( 1): 32 -40.
  • 9Wang CA, Jedlicka P, Patrick AN, et al. SIX1 induces lyrnphangiogenesisand metastasis v/a upregulation of VEGF-C in mouse models of breast cancer[J]. J Clin Invest, 2012, 122(5) : 1895 -1906.
  • 10Iwanaga R, Wang CA, Micalizzi DS, et al. Expression of Sixl in luminal breast cancers predicts poor prognosis and promotes increases in tumor initiating cells by activation of extracellular signal-regulated kinase and transforming growth factor-beta signaling pathways [ J ]. Breast Cancer Res, 2012, 14(4) : 4 - 14.

引证文献11

二级引证文献23

临床与实验病理学杂志
2014年 第4期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部