摘要
目的 探讨生长激素 (GH)在多囊卵巢综合征 (PCOS)患者促排卵中的作用。方法 测定 130例PCOS患者 (PCOS组 )及 10 7例正常妇女 (对照组 )的血中生殖激素及GH和胰岛素样生长因子Ⅱ (IGF Ⅱ )的基础水平 ,并应用GH辅助促排卵方案治疗 7例对人绝经期促性腺激素 (hMG)反应不良的PCOS患者 ,观察疗效。结果 PCOS患者血中GH水平明显降低 ,肥胖者更为明显 ,非肥胖与肥胖者分别为 (2 5 0± 1 33) μg/L及 (1 0 4± 0 47) μg/L ,而对照组肥胖与非肥胖者分别为 (2 95± 1 49)μg/L、(5 30± 2 2 6 ) μg/L(P均 <0 0 5 ) ;PCOS组肥胖者IGF Ⅱ水平为 (136± 2 7)nmol/L ,高于非肥胖者的 (12 3± 2 0 )nmol/L ,两者比较 ,差异有显著性 (P <0 0 5 )。应用GH辅助促排卵治疗 ,可以明显减少hMG用量 1～ 12支 ,缩短hMG刺激时间 3～ 12d ,增加优势卵泡的数量。结论 PCOS患者存在GH分泌障碍 。
Objective To study the effect of growth hormone (GH) on the outcome of ovulation induction in patients with polycystic ovary syndrome (PCOS). Methods We examined serum sex hormone, GH and insulin like growth factor Ⅱ(IGF Ⅱ) basal levels by radioimmunoassay in 130 PCOS patients and 107 normal women. In addition, we observed the effect of GH on the outcome of ovulation induction in 7 poor responders to human menopausal gonadotropin (hMG) treatment. Results The mean serum GH level is (2 50±1 33) μg/L and (1 04±0 47) μg/L respectively in nonobese and obese PCOS patients which were significantly lower than those in controls [(5 30±2 26) μg/L, (2 95±1 49) μg/L respectively, P <0 05]. The mean serum IGF Ⅱ level is (136±27) nmol/L in the obese PCOS patients, significantly greater than those in nonobese PCOS and controls ( P <0 05). When we used GH with hMG in 7 poor responders, the total amount of hMG required decreased from 1 to 12 amples and the duration of treatment shortened as compared with hMG alone. Conclusion There is abnormal GH secretion in patients with PCOS, GH may improve the outcome of ovulation induction by gonadotropin.
出处
《中华妇产科杂志》
CAS
CSCD
北大核心
2001年第1期36-39,共4页
Chinese Journal of Obstetrics and Gynecology
