摘要
目的探讨恩替卡韦治疗慢性重型乙型肝炎的临床效果。方法选择本院2013年1月-2014年1月收治的慢性重型乙型肝炎患者96例，将其随机分为观察组和对照组，每组48例，均接受基础支持治疗，对照组加用拉米夫定治疗，观察组加用恩替卡韦治疗，对比两组的临床效果及治疗前后肝功能和血清HBVDNA改善情况。结果观察组总有效率为97．92％．高于对照组的83．33％（P〈0．05）；观察组治疗后肝功能和血清HBVDNA明显优于对照组（P〈0．05）。结论恩替卡韦治疗慢性重型乙型肝炎的临床效果显著，能改善患者的生活质量，值得临床推广应用。
Objective To investigate the clinical effect of entecavir in the treatment of chronic severe hepatitis B. Methods 96 cases of patients with chronic severe hepatitis B in our hospital from January 2013 to January 2014 were selected,and were randomly divided into observation group and control group,48 cases in each group.All patients were treated with basic treatment,the control group were treated with lamivudine,observation group were treated with ente- cavir.The clinical effect was compared between two groups,and the liver function and serum HBV DNA improvement was observed before and after treatment.Results The total effective rate was 97.92% in the observation group,higher than 83.33% in the control group （P〈0.05）;After treatment,the liver function and serum HBV DNA in the observation groups was better than that in the control group respectively （P〈0.05）.Conclusion The clinical effect of entecavir treat- ment for chronic severe hepatitis B is significant,can improve the quality of life of patients,is worthy of promotion.
出处
《中国当代医药》
2014年第12期97-98,共2页
China Modern Medicine
