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西地那非对肺动脉高压的影响 被引量:2

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摘要 自1998年美国食品药品管理局(FDA)批准西地那非(Sildenafil,商品名Viagra)用于治疗男性勃起功能障碍后,人们对西地那非的研究和认识不断深入.
作者 陈红
出处 《中国医药导刊》 2001年第1期56-56,45,共2页 Chinese Journal of Medicinal Guide
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  • 2[2]Corbin JD, Francis SH. Cyclic GMP phosphodiesterase-5: target of sildenafil. J Biol Chem 1999, 274:13729~13732
  • 3[3]Wallid RM, Corbin JD, Francis SH, et al. Tissue distribution of phosphodiesterase families and the effects of sildenafil on tissue cyclic nucleotides, platelet function, and the contractile responses of trabeculae carneae and aortic rings in vitro. Am J Cardiol 1999, 83(suppl 5A) :3C~12C
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  • 6[6]Roberts J, Chen TY,Kawai N, et al. Inhaled nitric oxide reverses pulmonary vasoconstriction in the hypoxic and acidotic neoborn lamb. Circ Res 1993, 72:246~254
  • 7[7]Semigran M J, Cockrill BA,Kacmardk R, et al. Hemodynamic effects of inhaled nitric oxide in heart failure. J Am Coll Cardiol. 1994, 23:982~984 8 Kelly RA, Balligard J, Smith TW. Nitric oxide and cardiac function. Circ res 1996, 79:363~380
  • 8[8]Clarde WR, Uezono S, Chambers A, Doepfiner P. The type-Ⅲ phosphodiesterase inhibitor milrinone and type Ⅴ pde inhibitor dipyridamole individually and synergistically reduce elevated pulmonary vascular resistance. Pulm Pharmacol 1994, 7: 81~ 89
  • 9[9]Hanasato-N; Oka-M; Muramatsu-M; Nishino-M; Adachi-H;Fukuchi-Y E-4010, a selective phosphodiesterase 5 inhibitor, attenuates hypoxic pulmonary hypertension in rats. Am J Physiol 1999;277(2 Pt 1): L225~32
  • 10[10]Wemann J, Ullrich R, Hromi J, et al. Sildenafil is a pulmonary vasodilator in awake lambs with acute pulmonary hypertension. Anesthesiology 2000, 92:1702~1712

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