摘要
目的探讨糖尿病非增殖性视网膜病变(NPDR)患者视网膜神经纤维层厚度(RNFL)与其周围神经病变(DPN)严重程度关系,指导临床诊疗。方法将本院收治的80例NPDR患者分为轻度NPDR组、中度NPDR组、重度NPDR组,并将80例无NPDR糖尿病患者作为对照组。采用多伦多临床评分系统(TCSS)对周围神经功能进行评定,采用光相干断层扫描(OCT)测定所有NPDR患者的视网膜神经纤维层(RNFL)厚度,比较不同程度NPDR与RNFL的相关性,以及不同程度DPN与RNFL的相关性。结果不同NPDR组间平均、上方、下方RNFL厚度值存在显著差异(P<0.05),鼻侧、颞侧RNFL值无显著差异(P>0.05);不同DPN上方、下方RNFL厚度值存在显著差异(P<0.05),平均、鼻侧、颞侧RNFL厚度值无显著差异(P>0.05)。结论糖尿病患者NPDR、DPN与RNFL厚度均存在相关性,临床可根据DPN的程度评估患者的RNFL变化,推测NPDR严重程度,从而指导临床诊疗。
Methods 80 cases admitted to our hospital were divided into mild NPDR group, moderate NPDR group, severe NPDR group, and 80 cases of non-NPDR diabetic patients were classified as control group, the Toronto Clinical Scoring System （TCSS） were used to assess nerve function, and 80 patients were divided into non-DPN group NPDR, mild DPN group, moderate DPN group, severe DPN group, optical coherence tomography （OCT） were used to measure retinal nerve fiber layer （RNFL） thick- ness of all patients. Then The correlation of different levels of NPDR with RNFL and the correlation of different levels of DPN with RNFL were compared. Results there were significant difference between NPDR groups in average, above, below RNFL thickness （P〈0.05）, but there were no significant difference in nasal, temporal RNFL thickness （P〉0.05） ; there were sig- nificant difference between DPN groups in above, below RNFL thickness （P〈0.05）, but there were no significant difference in average,nasal, temporal RNFL thickness （P〉0.05）. Conclusion NPDR, DPN and RNFL thickness were correlated in dia- betes patients, we can evaluate RNFL changes, speculate NPDR severity according to the degree of DPN of patients to guide clinical practice.
出处
《中国实用神经疾病杂志》
2014年第5期19-21,共3页
Chinese Journal of Practical Nervous Diseases
