摘要
目的探讨2型糖尿病患者血尿酸水平与糖尿病周围神经病变(DPN)之间的相关性。方法 148例住院的2型糖尿病患者,根据是否合并DPN分为单纯2型糖尿病组(A组)82例,糖尿病周围神经病变组(B组)66例,所有患者均测量体质量指数(BMI)、血尿酸(SUA)、空腹血糖(FPG)、血脂、超敏C反应蛋白(CRP),糖化血红蛋白(HbA1c)等,采用神经缺陷评分(NDS)方法判断有无DPN。结果 B组的SUA、糖尿病病程、CRP、甘油三酯(TG)明显高于A组,相关分析表明SUA与NDS评分之间呈明显正相关(r=0.723,P<0.01)。结论血尿酸与2型糖尿病周围神经病变密切相关,血尿酸是否参与糖尿病周围神经病变的发病有待进一步研究。
Objective To investigate the correlation of serum uric acid with type 2 diabetic peripheral neuropathy. Methods One hundred and forty-eight type 2 diabetic patients were derided into group A （82 diabetic patients without peripheral neuropathy） and group B （66 diabetic patients with peripheral neuropathy）. The serum uric acid （SUA） and biochemical indi- cators were examined, peripheral neuropathy was diagnosed by the neuropathy disability score （NDS）. Results Patients in group B showed higher SUA, diabetes duration, CRP, TG than patients in group A, and SUA was positively correlated with NDS （r = 0. 723, P 〈 0. 01 ）. Conclusion SUA is closely correlated with type 2 diabetic peripheral neuropathy, whether SUA is in- volved in the pathogenesis of T2DM peripheral neuropathy remains to be studied.
出处
《临床医学》
CAS
2012年第9期26-27,共2页
Clinical Medicine
关键词
2型糖尿病
血尿酸
糖尿病周围神经病变
Type 2 diabetes
Serum uric acid
Diabetic peripheral neuropathy
