摘要
目的 研究人类相关转录因子3（human runt-related transcription factor 3,RUNX3）在乳腺癌组织中的表达水平及其临床病理意义.方法 应用组织芯片和免疫组化的方法评估RUNX3在256例乳腺癌组织中的表达水平,并通过统计学分析其与临床病理特征及患者预后的关系.结果 在256例乳腺癌组织中RUNX3阳性表达率和阴性率分别为32％ （83/256）和68％ （173/256）,RUNX3的表达水平与乳腺癌的病理分级呈高度相关（P=0.000）,RUNX3低表达提示5年总生存率低以及无瘤生存率低（P=0.000;P =0.001）.结论 RUNX3低表达与乳腺癌的进展以及预后差呈高度相关.
Objective To investigate the expression of RUNX3 in breast cancer tissues and its clinicopathological significance. Methods The expression of RUNX3 was evaluated by immunohistochemistry using a tissue microarray con taining 256 specimens of breast cancer patients. The relationship between expression levels of RUNX3, clinicopathologic parameters, and survival time of the patients were analyzed. Results Of the 256 breast cancer analyzed, RUNX3 nega- tive and positive staining cases were 32% （83/256） and 68% （173/256）, respectively. The expression of RUNX3 was significantly correlated with breast cancer histology grade （ P -- 0. 000 ） and low RUNX3 expression strongly correlated with worse 5 - year overall and disease - specific survival rates （ P = 0. 000 and P -- 0. 001, respectively）. Conclusions Reduced expression of RUNX3 is significantly correlated with breast cancer progression and predicts worse survival.
出处
《徐州医学院学报》
CAS
2014年第3期141-145,共5页
Acta Academiae Medicinae Xuzhou
基金
国家自然科学基金（81201636）
江苏省自然科学基金（BK2012139,BK2009089）
中国博士后科学基金（2012M511323）
关键词
RUNX3
乳腺癌
组织芯片
免疫组化
预后
RUNX3
breast carcinoma
tissue microanay
immunohistochemistry
prognosis
