摘要
目的 观察甲壳低聚糖对抗生素脱污染小鼠肠道菌群的影响 ,为进一步开发壳聚糖提供理论依据。 方法 用盐酸林可霉素复制肠道脱污染小鼠动物模型 ,将模型小鼠随机分为治疗组和对照组 ,治疗组灌服甲壳低聚糖 6 0 0mg· kg- 1·d- 1 ,对照组灌服等体积蒸馏水。 7天后分析肠道菌群。 结果 模型小鼠治疗组肠道菌群基本恢复正常 ,与对照组相比差异具有显著性意义 (P<0 .0 5 )。 结论 甲壳低聚糖对小鼠肠道菌群失调具有一定的调整作用。
Objective To investigate the effect of chitooligosaccharides on intestinal flora in mice which were decontaminated b y antibiotics and to provide a theoretical support for developing chitosan. Methods The animal model of bacteriun free mice i n intestine was replicated with Lincomycin hydrochloride, then mice were divided randomly into a treated group and a control group. The treated group was admini stered(ig) chitooligosaccharides at a does of 600 mg/kg·d for seven days, the c ontrol group was received the equal volume of distilled water for seven days. Th e level of intestinal microflora was measured after seven days. Result The intestinal flora in treated group near ly recovery to a normal status as compared with that of the control group (P<0 05). Conclusion It was indicated that chitooligoscchar ides could modulate the intestinal dysbacteriosis flora in mice.
出处
《实用预防医学》
CAS
2001年第1期21-22,共2页
Practical Preventive Medicine
基金
湖南省教委资助课题!(98B1 0 3)
关键词
甲壳低聚糖
抗生素
脱污染
肠道菌群
Chitooligosaccharides
Antibiotics
De contamination
Intestinal flora.
