摘要
目的探讨散发性戊型病毒性肝炎的临床特征。方法回顾性分析了71例戊型病毒性肝炎患者的临床和流行病学资料,分别比较老年组与非老年组、单纯戊型肝炎与重叠感染组生化指标。结果戊型肝炎呈全年散在发病;男性多于女性,男女比例为2.6:1,年龄分布在11-79岁,以青壮年高发;老年组患者与其他两组非老年组患者比较,TBIL峰值、ALT峰值差异有统计学意义(P<0.05),ALB低值、AST峰值差异无统计学意义(P>0.05),而老年组GGT峰值与11-40岁年龄组差别无统计学意义(P>0.05),与41-60岁年龄组差别有统计学意义((P<0.05);单纯戊型肝炎与重叠乙肝感染组比较,TBIL峰值、GGT峰值、ALB低值、ALT峰值、AST峰值差别无统计学意义(P>0.05);黄疸型67例(94.4%),重型肝炎5例,其中3例重叠乙肝感染,死亡1例,病危出院1例,转院3例。结论戊型病毒性肝炎呈全年散在发病,以青壮年和男性多见,以急性黄疸型为主,大多数患者预后良好,但有部分患者病情较重,重叠乙型肝炎感染及老年患者是造成戊型重型肝炎的危险因素。
Objective To explore clinical characteristics of sporadic patients with hepatitis E virus infection. Methods The clinical and epidemiologic data of 71 sporadic patients with hepatitis E virus infection were analyzed retrospectively. Biochemical indicators were compared for senile group and non-senile group, hepatitis E group and mixed infection group. Results Hepatitis E virus infection was characterized with sporadic distribution; most infections took place in winter and spring, in people aged 11 to 79. The ratio of male to female was 2.6：1, most patients were adolescents and young adults. There were significant difference for TBIL and ALT between senile group and non-senile group（P〈0.05）. There was no significant difference in low ALB and high AST between two groups（P〈0.05）. GGT peak was higher in senile group than that of 41-60 age group（P〈0.05）, but no significant difference was demonstrated in 11-40 age group（P〈0.05）. There was no significant difference in TBIL peak, GGT peak, ALB low value, ALT peak and AST peak between simple infection group and group with mixed infection. 71 sporadic patients with hepatitis E virus infection included 67 icteric patients（94.4%）, 5 severe hepatitis patients, 3 cases co-infected with HBV, 1 death, dying patients discharged from hospital and 3 patients transferred to anther hospital. Conclusion Hepatitis E virus infection was characterized by annual sporadic distribution,most patients were adolescents and young adults. Acute jaudice hepatitis was predominant mostly with good prognosis. Mixed infection and senile age are risk factors leading to hepatitis E virus infection.
出处
《中国热带医学》
CAS
2014年第2期225-226,255,共3页
China Tropical Medicine
关键词
戊型病毒性肝炎
散发性
临床特征
Hepatitis E virus
Sporadic patients
Clinical characteristics
