摘要
目的探讨银杏叶片联合尼莫地平治疗非痴呆型血管性认知功能障碍(VCIND)患者的临床效果。方法将120例VCIND患者随机分为治疗组和对照组各60例。对照组给予尼莫地平治疗,治疗组加用银杏叶片治疗,疗程8周。应用蒙特利尔认知评估量表(MoCA)和经颅多普勒超声(TCD)观察两组患者治疗前后认知能力和血管平均血流速度(Vm)变化,并检测血浆同型半胱氨酸(Hcy)水平变化。结果治疗后两组MoCA评分及血管Vm均有提高,血浆Hcy含量均有下降,治疗组改善更为明显,与对照组比较差异有统计学意义(均P<0.05)。结论银杏叶片联合尼莫地平治疗VCIND有协同作用,其机理尚需进一步研究证实。
Objective To discuss the clinical efficacy of ginkgo biloba tablet and nimodipine in treatment of vascular cognitive impairment non-dementia（VCIND） patients. Methods A total of 120 VCIND patients were randomly divided into treatment group（n=60） and control group（n=60）. Patients in control group were treatment of nimodipine, while those in treatment group were treated with of ginkgo biloba tablet. The course of treatment was 8 weeks. Montreal Cognitive Assessment（MoCA）and Transcranial Doppler（TCD） were used to observe the changes of congnitive function and the average blood flow velocity among VCIND patients. The level of Hcy was measured before and after therapy in all patients. Results Compared with before treatment, MoCA Score and Vm in two groups were higher after treatment. The level of Hcy was obviously decreased after treatment in two groups. There were significant differences in two groups（P0.05）. Conclusion Ginkgo biloba tablet combined with nimodipine for VCIND possessed has synergistic action. And the pharmacology needs further study.
出处
《中国热带医学》
CAS
2014年第2期210-212,共3页
China Tropical Medicine
关键词
银杏叶片
尼莫地平
血管性认知功能障碍
临床研究
Ginkgo biloba tablet
Nimodipine
Vascular cognitive impairment
Clinical study
