摘要
目的探讨代谢综合征与老年患者良性前列腺增生（BPH）术后早期复发的相关性。方法选择2008年8月至2013年3月在我院体检中心进行查体的BPH切除术后5年以上65～88岁患者152例，测量患者血压、体质量、身高，体质指数（BMI）、前列腺症状评分，生化分析包括晨空腹血糖（FGB）、三酰甘油（TG）、低密度脂蛋白胆固醇（LDL—c）、高密度脂蛋白胆固醇（HDL—C）、血前列腺特异抗原（PSA），同时行尿常规分析、最大尿流率（Qmax）测定，评估代谢综合征各相关指标与前列腺体积（PV）、国际前列腺症状（IPSS）评分、Qmax的相关性。结果伴代谢综合征的26例患者BPH术后复发11例，无代谢综合征患者126例术后复发27例，伴代谢综合征者BPH术后复发率明显高于对照组（χ2=12．76，P=0．000）。伴代谢综合征组患者血PSA值、PV、IPSS评分分别为（2．0±0．8）μg／L、（28．3±5．5）ml、（11．1±3．2）分，显著高于无代谢综合征患者（1．8±1．0）μg／L、（22．4±4．0）ml、（7．1±2．4）分（t=28．65、44．41、38．56，P=0．000、0．000、0．000），最大尿流率（14．8±5．3）ml／s，显著小于无代谢综合征患者（19．8±4．7）ml／s（t=59．48、P=0．000）。BPH术后复发组患者PV、IPSS评分与BMI、FGB、TG呈显著正相关（均P〈0．05），BPH术后无复发组患者PV、IPSS评分与BMI、FGB呈显著正相关（均P〈0．05），两组患者Qmax与BMI、收缩压、FGB均呈显著负相关（P〈0．05）。结论代谢综合征与老年患者BPH术后复发率增加有明显的相关性。
Objective To investigate the relationship between metabolic syndrome （MS） and early recurrence of benign prostatic hyperplasia （BPH） after prostatectomy in the elderly. Methods A total of 152 men aged 65 to 88 years with prostatectomy for more than 5 years were enrolled from August 2008 to March 2013. Blood pressure, body weight, body height, body mass index （BMD and international prostate symptom score （IPSS） were detected. Levels of fasting blood glucose （FBG）, triglyceride （TG）, low-density lipoprotein cholesterol （LDL-C）, high-density lipoprotein cholesterol （HDL-C）, prostate specific antigen （PSA） and maximum urinary flow rate （Qmax） were determined. The correlation of MS-related parameters with prostate volume, IPSS and Qmax were evaluated. Results BPH recurrence rate was significantly higher in patients with MS than without MS （11/26 vs 27/126, χ2=12.76, P〈0. 001）. PSA level, prostate volume and IPSS were significantly higher or larger in the MS group than in the non-MS group [（1.96±0. 82）μg/L vs. （1.81 ±0. 90）μg/L, （28.26±5.50） ml vs. （22.38±4.00）ml, （11.12±3.18） w （7.11±2.37）,F=28.654, 44.41, 38.56,respectively, P〈0. 001], while Qmax value was significantly lower in the MS group than in the non-MS group [（14. 77±5. 29） ml/s vs （19.80±4.70） ml/s, F=59.48, P〈0. 001]. The liner regression analysis showed that in postprostatectomy recurrence group, PV and IPSS had significantly positive correlations with levels of FBG and TG, and BMI （P〈0.05）, and had significantly positive correlations with BMI and FBG in non- recurrence group （P〈0.05）, while Qmax had a significantly negative correlation with BMI, systolic blood pressure and FBG in the two groups （P〈0.05）. Conclusions There is a significant relationship between MS and higher BPH recurrence in elderlypatients.
出处
《中华老年医学杂志》
CAS
CSCD
北大核心
2014年第4期389-392,共4页
Chinese Journal of Geriatrics
关键词
代谢综合征X
前列腺增生
复发
Metabolic syndrome X
Prostatic hyperplasia；Recurrence
