摘要
目的观察硫酸镁对妇科手术患者腰-硬联合麻醉中布比卡因蛛网膜下腔运动阻滞半数有效剂量（ED50）的影响。方法择期行妇科手术患者88例，随机分为两组。两组均采用腰-硬联合麻醉，分别在蛛网膜下腔阻滞后静脉注射硫酸镁25mg／kg（M组）或等量生理盐水20ml（C组）。采用序贯法进行试验，布比卡因剂量从6mg开始，运动阻滞达到Bromage3分则下一例的剂量减少1mg，反之则增加1mg，Dixon-Mood法计算布比卡因ED5。及其95％可信区间（CI）。结果C组布比卡因蛛网膜下腔阻滞运动阻滞ED50为7．827（95％CI7．341-8．345）mg，M组ED50为7．014（95％CI6．618-7．434）mg，M组明显低于C组（P〈0．05）。结论单次静脉注射硫酸镁25mg／kg可以明显降低布比卡因蛛网膜下腔运动阻滞的ED50。
Objective To investigate the effect of a single intravenous injection of magnesium sulfate on the median effective dose（EDs0 ） of intrathecal bupivacaine in patients undergoing gynecological surgery. Methods Eighty-eight ASA I or II patients for elective gynecological surgery were enrolled in this double-blind, randomized study under combined spinal epidural anesthesia. These patients were randomly assigned to one of the following two groups. Group M （n=44） received intravenous injection of 25 mg/kg MgSO4, and group C（n=44） received the same volume of saline. The ED50 was determined by an up-and-down sequential method. The initial dose of bupivacaine of 6 mg. If satisfactory motor block was obtained （Bromage score=3）, the dose in the next case would be decreased 1 mg, or otherwise, increase 1 mg. Dixon-Mood method was used to calculate the ED50. Results The ED50 of intrathecal bupivacaine was 7. 827 mg（95%CI 7. 341-8. 345 mg） in group C and 7. 014 mg（95%CI 6. 618-7. 434 mg） in group M. The ED50 in group M was significantly lower than in group C （P〈0. 05）. Conclusion A single intravenous injection of 25 mg/kg MgSO4 could decrease the median effective dose of intrathecal bupivacaine.
出处
《临床麻醉学杂志》
CAS
CSCD
北大核心
2014年第4期343-345,共3页
Journal of Clinical Anesthesiology
