摘要
目的分析先天性心脏病患儿围术期血浆镁浓度降低与节性心动过速(JET)的关系,并观察围术期补充硫酸镁的预防作用。方法 99例先天性心脏病择期在心肺转流(CPB)下手术患儿,随机分为三组:A组(30例)、B组(40例)分别在CPB复温期间补充硫酸镁25、50 mg/kg,C组(29例)为生理盐水组。各组在CPB前(T1)、CPB开始后10 min(T2)、给硫酸镁后10 min(T3)、转入ICU时(T4)测定血浆镁离子浓度。结果 A组有2例、C组有5例发生JET,明显多于B组(0例)(P<0.05)。T3时B组镁离子浓度显著高于T1、T2时和A、C组(P<0.01);T4时A、B两组镁离子浓度明显高于C组(P<0.01)。结论 CPB期间补充硫酸镁可降低JET发生率。
Objective To analyze the relationship between the hypomagnesemia and the incidence of junctional ectopic tachycardia （JET） in pediatric patients after heart surgery, and observe the preventive role of magnesium. Methods Ninetynine pediatric patients with congenital heart diseases undergoing cardiopulmonary bypass （CPB） were randomly assigned into three groups： patients in the groups A （thirty cases） and B （forty cases） received intravenous magnesium 25, 50 mg/kg, respectively, during the rewarming phase of CPB, but in the group C （twenty nine cases） the patients only received normal saline The plasma concentrations of magnesium were measured at following time points： before CPB （T1）, 10 min after CPB （T2）, 10 min after magnesium （T3）, and when the patient was transferred into ICU （T4）. Results Two patients in the group A and five in the group C encountered JET. The concentration of magnesium was higher in group B at T3 than at T1 and T2 and groups A and C（P〈0. 01）, but at T4, groups A and B had higher magnesium than the group C （P〈0. 01）. Conclusion Supplementation with MgSO4 during CPB can reduce the incidence of JET.
出处
《临床麻醉学杂志》
CAS
CSCD
北大核心
2011年第7期659-660,共2页
Journal of Clinical Anesthesiology
关键词
硫酸镁
节性心动过速
心肺转流
儿童
Magnesium sulfate
Junctional ectopic tachycardia
Cardiopulmonary bypass
Pediatric
