摘要
目的探讨静脉注射地塞米松对重度妊娠高血压合并血小板减少(HELLP)综合征的疗效及预后效果。方法选取48例妊娠高血压合并HELLP综合征患者为观察组,根据患者血小板计数,将其分为Ⅰ级组16例,Ⅱ级组18例,Ⅲ级组14例;并选取本院同期分娩50例重度高血压孕妇为对照1组,及100例正常健康孕妇为对照2组,对比各组患者的临床表现、母婴结局和预后情况。结果与对照1组及对照2组相比,合并HELLP综合征患者乳酸脱氢酶、妊娠并发症及围产儿死亡率较高(P<0.05),血小板计数较低(P<0.05);与对照2组相比,对照1组妊娠并发症发生率较高(P<0.05),其余两项两组差异无统计学意义(P>0.05);Ⅰ级组患者与Ⅱ级及Ⅲ级组患者相比,乳酸脱氢酶、妊娠并发症以及围产儿死亡率较高(P<0.05);Ⅱ级组与Ⅲ级组相比,乳酸脱氢酶较高(P<0.05),,血小板计数较低(P<0.05),但两者妊娠并发症及围产儿死亡率无显著性差异(P>0.05)。结论 HELLP综合征患者的预后与临床分级有密切联系,Ⅰ级组的预后效果较Ⅱ级组及Ⅲ级组差,对孕妇进行及时救治,适时终止妊娠,能有效降低产妇并发症发生率及围产儿死亡率,有利于母婴预后。
Objective To investigate the effect and the prognosis of intravenous dexamethasone in treating severe pregnancy- induced hypertension complicating thrombocytopenia syndrome （HELLP）. Methods Forty-eight cases of gestational hypertension complicating HELLP were selected as the observation group and divided into the class Ⅰ（16 cases）, class Ⅱ（18 cases） and class Ⅲ （ld cases） groups according to the platelet count; contemporaneous 50 pregnant women with severe hypertension were selected as the control group 1 and 100 cases of normal healthy pregnant women were selected as the control group 2. The clinical manifestations, maternal and neonatal outcomes, and prognosis were compared among the various groups. Results The lactate dehydrogenase level, pregnancy complications and perinatal mortality rate in the observation group were higher than those in the control group 1 and control group 2（P 〈0. 05）;the oc- currence rate of pregnant complications in the control group 1 was higher than that in the control group 2（ P 〈 0.05）, other two items had no statistical difference; the lactate dehydrogenase level, pregnancy complications and perinatal mortality rate in the class Ⅰ group were higher than those in the class Ⅱ and the class Ⅲ groups（ P〈0.05）; the lactate dehydrogenase level in the class Ⅱ group was significant higher than that in the class Ⅲ group（P〈0. 05）, but both pregnancy complications and perinatal mortality had no statistical differences（ P 〉 0.05）. Conclusion The prognosis of the patients with HELLP is closely related with the clinical classification, which in the class I is worst compared with the class Ⅱ and Ⅲ groups. Timely treatment for pregnant women and the timely termination of preg- nancy can effectively reduce the occurrence rate of parturient complications and perinatal mortality and are conduce to the maternal and neonatal prognosis.
出处
《中国药业》
CAS
2014年第7期70-72,共3页
China Pharmaceuticals
关键词
妊娠高血压
重度
血小板减少综合征
乳酸脱氢酶
severe pregnancy- induced hypertension
thrombocytopenia syndrome
lactate dehydrogenase
