摘要
目的探讨血培养中凝固酶阴性葡萄球菌的临床价值。方法回顾性分析86例血培养CNS阳性患者的临床资料、CNS检测时间、药敏结果以及患者治疗情况，分析其临床意义。结果CNS感染所致茵血症42例（48．8％），污染菌44例（51．2％）；污染茵检出时间显著长于病原菌检出时间（P〈0．01）；病原菌与污染茵对头孢西丁、青霉素、头孢呋辛、头孢唑林、庆大霉素、万古霉素、环丙沙星等抗茵药物耐药性比较差异均无统计学意义（P〉0．05），对万古霉素均敏感；42例感染患者经治疗均得以控制。结论血培养中检出CNS需根据实验室及相应临床资料区分致病茵或污染菌，虽然万古霉素为CNS敏感抗生素，但仍应避免长期大剂量应用，以避免耐药菌株的产生。
Objective To investigate the clinical value of coagulase-negative staphylococci （CNS） in blood culture. Methods The clinical data, CNS detection time, susceptibility results and treatment outcome of 86 patients with positive blood cultures CNS were retrospective analyzed, and the clinical value was analyzed. Results There were 42 patients（48.8% ） with bacteremia caused by CNS infection, and 44 cases （51.2% ） with contaminating bacteria; contaminating bacteria detection time was significantly longer than pathogens（ P 〈0.01 ）. There was no significantly difference in resistance to bac- teria cefoxitin, penicillin, cefuroxime, cefazolin, gentamicin, vancomycin, ciprofloxacin between pathogenic bacteria and contaminating （ P 〉 0. 05 ）, and they were susceptible to vancomycin; 42 patients with infection were under control. Conclusions Identification of pathogenic bacteria and con- taminating CNS detected in blood culture should be based on laboratory and clinical data corresponding, although CNS is sensitive to vancomycin antibiotics, but should avoid long-term and high-dose application in order to avoid drug-resistant strains.
出处
《中国实用医刊》
2014年第9期46-48,共3页
Chinese Journal of Practical Medicine
关键词
血培养
凝固酶阴性葡萄球菌
临床价值
Blood culture
Coagulase negative staphylococcus
Clinical value
