摘要
目的:为探讨中医药联合序贯疗法根除Hp相关性胃炎的治疗效果及相关费用情况。方法:240例慢性胃炎病人随机分为6组,平均每组40例,分别使用不同治疗方案:治疗组使用纯西药治疗,中医对照组则在序贯治疗方案基础上加用三九胃泰和/或胃苏颗粒治疗。治疗10 d后停用抗生素,维持胃黏膜保护剂或三九胃泰和/或胃苏颗粒治疗治疗2周。停药1月后复查Hp情况。治疗前后记录患者《中医脾胃系疾病PRO量表》得分情况、相关治疗费用。结果:6组病人根除率情况差异无统计学意义。中西医结合治疗组较纯西医治疗组患者具有较好的生存质量改善(心理领域和环境领域)。6组的成本效用比分别为:2377.19元/QALYs、2656元/QALYs、2863.42元/QALYs、2882.24元/QALYs、2524.82元/QALYs、2084.94元/QALYs。C2组的成本效用比、增量成本效用比低于其他组。结论:在Hp根除率差异无统计学意义的情况下,使用泮托拉唑+阿莫西林+克拉霉素缓释片+奥硝唑+中成药三九胃泰及胃苏颗粒组进行治疗更加经济实惠,能有效改善患者症状,有望作为Hp根除治疗优选方案。
Objective ：To evaluate the treatment effect and costs with Chinese medicine combined sequential therapy to eradicate Hp- associated chronic gastritis. Methods ：240 cases of Hp- associated chronic gastritis patients were randomly divided into six groups, with an average of 40 people per group, respectively, using different treatment regimens. The treat- ment group used pure Western medicine and the control groups treated with Chinese medicine San^iu Weitai and/or Weisu particle combining sequential treatment programs. Antibiotics and PPI were discontinued after 10 days sequential therapy, and to maintain gastric mucosa protection agent or Sanjiu Weitai for two weeks. One month later,the Hp condition was re- corded to compare with each group. By recording before and after treatment, the scores of spleen and stomach disease PRO scale （SSD -PRO） and cost of treatment were acquired to evaluate the treatment effect. Results ：The eradication rates of six groups had no significant difference. The combination of Chinese medicine control groups had better quality of life im- provement （psychological dimension and the environment dimension） compared with pure Western medicine treatment groups. Six groups＇ treatment cost - utility ratios （CUR） were ： 2377. 19yuan/QALYs, 2656yuan/QALYs, 2863.42yuan/ QALYs,2882.24yuan/QALYs,2524.82yuan/QALYs and 2084.94yuan/QALYs. The CUR and increased cost utility ratio （ICUR） in group C2 were lower than those of the other groups. Conclusion：The group of the triple sequential therapy with pantoprazole ,clarithromycin and ornidazole plus Sanjiu Weitai capsule and Weisu granule obtained better cost utility ratio and quality of life when treating chronic gastritis. The program is expected as one of the preferred Hp eradication therapies.
出处
《中华中医药学刊》
CAS
2014年第4期817-819,共3页
Chinese Archives of Traditional Chinese Medicine
基金
广东省中医药强省课题面上项目(2010076)
关键词
幽门螺杆菌
患者结局报告
序贯疗法
成本效用分析
Helicobacter pylori （Hp）
patient reported outcomes （PRO）
sequential therapy
cost utility analysis
