摘要
目的 探讨贲门癌患者手术前后血清同型半胱氨酸（Hcy）水平变化及临床意义.方法 采用循环酶法检测102例贲门癌患者（其中男性69例）和50名健康人（健康对照组）外周血Hcy的水平.结果 男性贲门癌组明显高于健康对照组,差异有统计学意义（t=5.143,P=0.001）;男性贲门癌患者术后外周血血清Hey水平显著低于术前（均P＜0.05）,术后1个月血清Hey水平明显下降接近于健康对照组;Ⅳ期男性患者血清Hcy水平低于其他TNM分期组,且差异有统计学意义（t值分别为2.306、3.285,P值分别为0.030、0.002）;男性患者肿瘤长度＞5cm组Hcy水平明显低于＜3cm、3 ～5 cm组,且差异有统计学意义（t值分别为2.461、2.147,P值分别为0.017、0.038）;Logistic回归分析,Hey与男性贲门癌发病有一定的相关性,OR值为1.136（95％CI 1.010～1.278,P=0.033）.男性贲门癌患者淋巴结转移与Hcy含量呈负相关（OR=0.865,P=0.010）.结论 Hcy水平与男性贲门癌发病风险呈正相关,且与贲门癌的进展有密切关系.
Objective To evaluate the changes and clinical significance ol the serum levels of homocysteine （Hcy） in gastric cardia cancer patients before and after surgery. Methods Serum Hcy concentrations of 102 patients with gastric cardia cancer （including 69 case of males） and 50 healthy human were measured by enzymatic cycling assay. Results Total Hcy levels were significantly increased in male patient group compared with the levels in control group （t = 5.143, P = 0.001）. Hcy levels were significantly lower in postoperative group compared with preoperative group [（17.08±5.31） p, mol/L vs （20.34±9.26） p, mol/L, （14.07±4.87） p, mol/L vs （20.34±9.26） p, mol/L, P 〈 0.05]. Compared with IV stage group and other TNM stage groups, significantly lower levels of Hcy were detected in patients with gastric cardia cancer （t = 2.306, 3.285, P = 0.030, 0.002）. Hcy levels in patients with gastric cardia cancer were also significantly higher than those in the tumor length 〈 3 cm, 3-5 cm and 〉 5 cm groups （t = 2.461, 2.147, P = 0.017, 0.038）. Multiple logistic regression analysis indicated a statistically significant association between serum Hcy concentration and gastric eardia cancer incidence （OR = 1.136, 95 % CI 1.010-1.278, P = 0.033）. Increasing serum Hey levels were significantly associated with a decreasing risk of metastatic lymph node （OR -- 0.865, P = 0.010）. Conclusion Serum Hcy levels are directly associated with risk of male patients with gastric cardia cancer, and play important roles in the development of gastric cardia cancer.
出处
《肿瘤研究与临床》
CAS
2014年第3期156-159,共4页
Cancer Research and Clinic
关键词
贲门肿瘤
同型半胱氨酸
Gastric cardia neoplasms
Homocysteine
