摘要
目的探讨食管癌患者手术前后血清同型半胱氨酸（Hcy）水平变化及其临床意义。方法采用循环酶法检测168例食管癌患者和50名对照者外周血Hcy水平。结果食管癌组外周血Hcy水平明显高于对照组[（19．6±6．1）μmol／L比（13．0±2．3）μmol／L，P=0．001]；食管癌患者术后第5天、术后1个月、3个月血清Hcy水平显著低于术前[（17．0±8．5）、（15．8±6．4）、（12．8±5．6）μmol／L比（20．6±9．1）μmo｜／L，均P〈0．05）]；术后3个月血清Hey水平接近于对照组；T4患者血清Hcy水平高于其他T分期组[（29．5±1．7）μmol／L比（18．5±6．9）、（18．8±8．0）、（20．6±8．8）μmol／L，均P〈0．0011；肿瘤长度〉5cm组血清Hcy水平明显高于〈3cm、3～5cm组[（23．6±9．6）μmol／L比（18．1±6．3）、（19．6±6．6）μmol／L，P=0．036、P=0．0211；淋巴结转移与否食管癌患者的血清Hcy水平差异无统计学意义[（20．2±9．3）μmol／L比（20．3±7．6）μmol／L，P=O．897]，脉管阳性组血清Hcy水平低于阴性组[（16．7±3．4）p,mol／L比（21．1±8．9）p,mol／L，P=0．007]。结论血清Hcy水平与食管癌的进展密切相关。
Objective To evaluate the changes and clinical significance of the serum level of homocysteine （Hcy） in esophageal cancer patients before and after surgery. Methods The serum Hcy concentrations of 168 patients with esophageal cancer and 50 healthy individuals were measured by enzymatic Cycling. Results Total Hey levels were significantly raised in patients group when compared with the levels in control group [（19.6±6.1） μmol/L vs （13.0±2.3） μmol/L, P = 0.001]. Hcy levels were significantly lower in postoperativepatients groups compared with preoperativegroup [（17.0±8.5）, （15.8±6.4）, （12.8±5.6） μmol/L vs （20.6±9.1） μmol/L, all P 〈 0.05]. Also, Hcy levels in patients with esophageal cancer were significantly higher than in the tumor length〉 5era group and the 〈3 cm, 3-5 cm group [（23.6±9.6） μmol/L vs （18.1±6.3）, （19.6±6.6） μmol/L, P = 0.036, P = 0.021]. Compared with other T stage groups, significantly higher level of Hcy was found in T4 stage group [（29.5±1.7） μmol/L vs （18.5＋6.9）, （18.8±8.0）, （20.6＋8.8） μ mol/L, all P 〈 0.001]. There was no significant difference between the mean Hey concentrations of the node-positive and node- negative group [（20.2±9.3） μmol/L vs （20.3±7.6） μmol/L, P = 0.897]. Compared with negative lymphangial tumor-cells thrombus group, positive group had low Hey level [（16.7±3.4） μmol/L vs （21,1±8.9） μmol/L, P = 0.007]. Conclusion These results showed that serum Hcy levels play important roles in the development of esophageal cancer.
出处
《肿瘤研究与临床》
CAS
2012年第12期825-827,830,共4页
Cancer Research and Clinic
