摘要
目的:检测糖尿病(DM)及其并发症患者糖化血红蛋白(HbAlc)、3-硝基酪氨酸(3-NT)及其他生化指标的水平,探讨上述指标与DM及其并发症的关系,为DM患者的早期诊断及治疗提供依据。方法:选择DM患者64例,其中单纯DM患者18例(单纯DM组),DM并发症患者46例(DM并发症组),其中并发周围神经病变患者16例(DM并发周围神经病变组),并发其他并发症患者30例(DM并发其他并发症组);选择正常对照20人(正常对照组)。分别检测各组研究对象的HbA1c、3-NT、空腹血糖(FBG)、总胆固醇(TC)、甘油三酯(TG)、血尿素氮(BUN)、血肌酐(Cre)水平。结果:单纯DM组和DM并发症组患者的HbA1c、3-NT、FBG、TG和Cre水平均高于正常对照组(P<0.05);DM并发其他并发症组、DM并发周围神经病变组的3-NT水平明显高于单纯DM组(P<0.05);3-NT和TG水平随DM并发症的病情进展有逐渐升高的趋势,以DM并发周围神经病变组为最高。多元逐步回归分析,体质量指数(BMI)、TC与3-NT水平呈线性回归关系(r=0.272,r=0.216,P<0.05)。结论:HbAlc和3-NT对DM及其并发症的早期诊断及治疗监测具有重要意义,3-NT的检测对于DM并发症的进一步诊断有重要意义。
Objective To detect the levels of glycosylated hemoglobin Alc（HbAIe）, 3-nitrotyrosine（3-NT）and other biochemical indexes in the patients with diabetes mellitus （DM）and its complications, and to discuss the relationship between these indexes and DM and its complications, and to provide basis for diagnosis and therapy of DM patients. Methods 64 DM patients were selected, including 18 DM patients （simple DM group） and 46 DM complication patients （DM complication group）, which included 16 DM peripheral neuropathy patients （DM peripheral neuropathy group） and 30 DM other complication patients（DM other complication group）; 20 non-diabetic subjects （normal control group） were selected. The levels of HbAlc, 3-NT, fasting blood glucose （FBG）, total cholesterol （TC）, triglyeeride （TG）, blood urea nitrogen （BUN）, and serum creatinine （Cre） of the objects in various groups were detected. Results The levels of HbAlc, 3-NT, FBG, TG, and Cre o{ the patients in simple DM group and DM complication group were higher than those in normal control group（P〈0.05） the 3-NT levels of the patients in DM other complication group and DM peripheral neuropathy group were higher than those in simple DM group（P〈0.05） ; the levels of 3-NT and TG had an increasing trend with the development of DM complications and the patients in DM peripheral neuropathy group had the highest levels of 3-NT and TG. The results of regression analysis showed that there were linear regression relationship between BMI, TC and 3-NT （r=0. 272, r=0. 216, P〈0. 05）. Conclusion HbAlc and 3-NT play an important role in early diagnosis and treatment monitoring of DM and its complications. 3-NT testing has great significance for the further diagnosis of DM complications.
出处
《吉林大学学报（医学版）》
CAS
CSCD
北大核心
2014年第2期379-383,共5页
Journal of Jilin University：Medicine Edition
基金
国家级大学生创新性实验计划项目资助课题(101020136)
关键词
糖尿病
糖化血红蛋白
3-硝基酪氨酸
diabetes mellitus
glycosylated hemoglobin Ale
3-nitrotyrosine
