摘要
肝癌是占全球发病率第5、致死率第3的恶性肿瘤。在我国,每年新发现的肝癌患者人数占全球的一半以上。虽然在早期诊断和治疗措施方面已有很大的进步,但是大部分肝癌患者被发现时已属晚期,而且针对肝癌的以手术为主的综合治疗疗效仍有限。近十多年的研究使肿瘤干细胞的概念深入人心,越来越多的证据表明肿瘤干细胞与肿瘤的生长、耐药、转移和复发等密切相关,使人们对肝癌的发生和发展有了新的认识,为肝癌的治疗提供了新的方向。
Hepatocellular carcinoma （HCC） is the fifth most common and third most deadly malignancy in the world. And almost half of the universal newly found HCC patients are Chinese. Although there have been great progress on diagnosis and treatment of HCC, the outcome of HCC patients who have undergone systematic therapy including liver resection still remain poor. During this decade, the concept of cancer stem cells （CSCs） have become a hotspot in cancer research. They are considered to be responsible for tumor growth, chemoresistance, metastasis and tumor relapse. With a deeper understanding of liver cancer stem cells （LCSCs）, researchers tend to treat LCSCs as the therapeutic target of HCC.
出处
《中华临床医师杂志（电子版）》
CAS
2013年第24期330-332,共3页
Chinese Journal of Clinicians(Electronic Edition)
基金
国家自然科学基金(81272648
81302168)
关键词
肝肿瘤
肿瘤干细胞
Liver neoplasms
Neoplastic stem cells
