摘要
为了探明吡喹酮脂质体在山羊体内的代谢动力学 ,给山羊 1次静脉推注吡喹酮脂质体 3 m g/kg,取 2 4h内不同间隔时间的血样测血药质量浓度 .结果表明 ,血药质量浓度 -时间曲线符合无吸收因素的一室开放模型 ,其药物代谢动力学参数 :消除半衰期为 (10 .0 0± 0 .5 9) h;消除速率常数β为 (0 .0 6 9± 0 .0 0 4) h- 1 ;初始质量浓度为(18.81± 0 .46 ) μg/10 0 m L;维持有效质量浓度时间为 (2 0 .0 1± 1.18) h;表观分布容积为 (2 .91± 0 .42 ) 10 0 m L/kg;清除率为 (1.93± 0 .2 9) 10 0 m L/(kg· h) ;药时曲线下面积为 (2 71.6 7± 2 1.0 7) μg· h/10 0 m L.
After goats were injected intravenously 3 mg/kg praziquantel liposome,blood was collected for several times within 24 h to determine blood drug concentration.The results show that the time curve of blood drug concentration in goats corresponds to one compartment model of no absorpbabal factor.The pharmacokinetic parameters read as follows:Elimination half life period is (10.00±0.59) h, elimination rate constant (β) is(0 069±0 004)/h,preliminary concentration (B) (18 81±0 46) μg/100 mL,time of effective blood drug concentration (TCP) (20 01±1 18) h,apparent volume of distribution (V d) (2 91±0 42)·100 mL/kg,clearance (CLB) (1 93±0 02)·100 mL/(kg·h),area under the curve (271 67±21 07)·μg·h/100 mL.
出处
《湖南农业大学学报（自然科学版）》
CAS
CSCD
2000年第6期436-438,共3页
Journal of Hunan Agricultural University(Natural Sciences)
基金
世界银行贷款项目! (JRMC)
