摘要
目的探讨儿童急性淋巴白血病(ALL)血清瘦素、血清脂联素和抵抗素水平的变化及其临床应用价值。方法选取接受化疗的ALL患儿38例为研究对象,选取同期体检的健康儿童40例为对照组,分别应用ELESA酶联免疫法测定2组清瘦素、血清脂联素和抵抗素水平。结果与对照组相比,ALL组患儿初诊时血清脂联素显著下降,而血清瘦素、抵抗素水平显著上升,差异有统计学意义(P<0.05)。不同化疗效果的患儿,其血清瘦素、血清脂联素和抵抗素水平存在差异,其中CR、PR血清脂联素显著高于NC、PD患儿,而血清瘦素、抵抗素水平显著低于NC、PD患儿,差异有统计学意义(P<0.05)。血清瘦素+脂联素+抵抗素联合检测的灵敏性为97.25%,特异性为99.28%,准确性为96.37%显著高于单一检测,差异有统计学意义(P<0.05)。结论血清瘦素、血清脂联素和抵抗素水平的变化与ALL发生有密切的关系,通过测定三者水平能有效预测患者病情的进展及预后。
Objective To explore the clinical value and levels of erum leptin, adiponectin, resistin in children with acute lymphoblastic leukemia （ALL）. Methods 38 children with ALL and 40 children with physical examination were determined by ELISA and ELESA. Results The levels of serum leptin, resistin in the ALL group decreased and the levels of adiponectin increased signifi- cantly （P 〈 0.05）. Serum adiponectin level in CR, PR children was significantly higher than NC, PD children, while the levels of serum leptin, adiponectin, resistin were significantly lower than those of NC, PD children （ P 〈 0.05 ）. The sensitivity, specificity and accuracy of adiponectin serum leptin, resistin and detection were significantly higher than those of the single test （ P 〈 0. 05）. Conclusion Changes of serum leptin, adiponectin, resistin levels were closely related with oc- currence of ALL. Measurement of the three indicators can predict the progress of the disease and pro^nosis of patients.
出处
《实用临床医药杂志》
CAS
2014年第3期130-132,共3页
Journal of Clinical Medicine in Practice
