摘要
目的:研究急性髓系白血病(AML)初诊和化疗过程中血清脂联素、瘦素和抵抗素水平的变化。方法:选取35例接受相同的化疗方案的AML患者,选取50例健康成年人作为对照组。用双抗体夹心ABC-ELISA法测定治疗过程中血清中的的脂联素、瘦素和抵抗素水平的变化,同时测定血清中的乳酸脱氢酶(LDH)浓度。结果:初诊时患者血清中的脂联素和抵抗素水平明显低于正常对照组(P<0.001),而瘦素表达差异无统计学意义(P=0.368)。经过化疗后,AML患者血清中的脂联素和抵抗素水平呈现明显上升的趋势(P<0.001),瘦素仍差异无统计学意义(P=0.849)。相关性分析显示治疗过程中的脂联素和抵抗素水平与LDH呈现明显的负相关(分别为r=-0.539,P=0.005和r=-0.587,P=0.005)。结论:AML初诊时血清中的脂联素和抵抗素水平明显降低,而且这两种脂肪素的水平随着AML治疗的进展逐渐趋于正常。不过血清中的瘦素却没有表现出与AML的相关性。
Objective To investigate adiponectin,leptin,and resistin levels at diagnosis and during chemotherapy in patients with acute myeloid leukemia（AML）.Methods ABC-ELLSA was used to detect the adiponectin,leptin,and resistin levels in 35 AML patients and 50 normal controls.The corresponding lactate dehydrogenase（LDH） levels were also recorded.Results At diagnosis,mean adiponectin and resistin levels were low compared with controls（P0.001）,but the leptin levels had no difference（P=0.368）.During the chemotherapy,adiponectin and resistin increased significantly（P0.001）,and the leptin levels still had no significant difference（P=0.849）.The levels of adiponectin and resistin were negatively correlated with LDH during therapy（r=-0.539,P=0.005 and r=-0.587,P=0.005,respectively）.Conclusion Low adiponectin and resistin are present at the AML diagnosis.Those two adipocytokines alterations are progressively restored during therapy.Whereas the serum leptin is not correlated with AML.
出处
《吉林医学》
CAS
2012年第12期2473-2474,共2页
Jilin Medical Journal
