摘要
目的观察抵当汤对阿尔茨海默病(AD)大鼠学习记忆能力的影响。方法将40只雄性Wistar大鼠随机分为假手术组、模型组、安理申组和抵当汤组。采用右侧海马一次性注射聚集态Aβ25-35方法制备AD大鼠模型,造模成功后进行定位航行实验及空间探索实验,之后连续灌胃给药,疗程为8周,用药结束后继续进行Morris水迷宫实验,观察各组大鼠学习记忆能力的改变。结果与模型组比较,各给药组大鼠逃避潜伏期明显缩短(P<0.05或P<0.01),抵当汤组较安理申组缩短更明显(P<0.05)。同时药后安理申组和抵当汤组大鼠跨台次数较实验前明显增加(P<0.05),与安理申组相比抵当汤组增加更显著(P<0.05)。结论抵当汤可以改善AD大鼠的学习记忆能力。
Objective To observe the effects of Didang decoction on learning and memory ability in rats with Alzheimer disease （AD）.Methods 40 male Wistar rats were randomly divided into pseudo operation group,model group,aricept group and Didang decoction group.AD model rats were made using the right hippocampus one-time injection state of aggregation of A beta 25-35 method.After the modeling,navigation test and space exploration experiments were per- formed,and then continuous oral administration for 8 weeks,after the medication Morris water maze experiment was con- tinued to observe the changes of learning and memory ability in different groups of rats.Results Compared with model group,the escape latent period of rats in each treated group was shortened obviously （P〈0.05 or P〈0.01）,it was more significantly shortened in Didang decoction group as compare to that in Aricept group （P〈0.05）.At the same time,after administration,the step-down frequency of rats was significantly increased than before the experiment in both Aricept group and Didang decoction group （P〈0.05）,and it was more significantly increased in Didang decoction group com- pared with Aricept group （P〈0.05）.Conclusion Didang decoction can improve the learning and memory ability of rats with Alzheimer disease.
出处
《中国当代医药》
2014年第8期16-18,共3页
China Modern Medicine
基金
国家中医药管理局重点学科资助项目
山东省中医药科技发展计划(2013ZDZK-004
2011-077
2013-044)
关键词
抵当汤
阿尔茨海默病
学习记忆
Didang decoction
Alzheimer disease
Learning and memory
