摘要
目的分析急性绒毛膜羊膜炎的用药方案以及对并发症的影响。方法选取2008年3月至2012年6月在深圳市蛇口人民医院进行治疗的急性绒毛膜羊膜炎的患者58例,根据治疗方案的不同分为两组,分别为甲硝唑+头孢曲松钠组和单用头孢曲松钠组,各29例,观察用药方法对两组患者及新生儿的影响、出现孕妇并发症的发生情况。结果甲硝唑+头孢曲松钠组的分娩后高热持续时间、活化部分凝血活酶时间、凝血酶原时间和产后出血率均显著低于单用头孢曲松钠组患者[(1.14±0.51)d vs(2.35±0.37)d]、[(38.75±3.16)s vs(46.61±4.27)s]、[(12.59±2.52)s vs(17.63±2.75)s]、[10.34%vs 17.24%](P<0.05);甲硝唑+头孢曲松钠组的新生儿肺炎、新生儿呼吸窘迫综合征、新生儿黄疸以及1 min Apgar评分<7的例数均显著小于单用头孢曲松钠组(P<0.05);其寒战、抽搐、麻痹性肠梗阻以及子宫复旧不良的患者例数也显著低于单用头孢曲松钠组的患者(P<0.05)。结论联合用药治疗急性绒毛膜羊膜炎可以显著降低患者并发症的发生率,并改善其预后。
Objective To analyze the therapy for acute chorioamnionitis and the influence on the complications.Methods A total of 58 acute chorioamnionitis patients Shenzhen Shekou People＇s Hospital during Mar.2008 and Jun.2012 were selected for this study,the patients were divided into two groups according to the way of therapy：metronidazole＋ceftriaxone group and single-use ceftriaxone group,29 cases in each group.Then effect on patients,neonate,complications of patients of the two groups were observed.Results The duration of hyperpyrexia,APTT,PT and the postpartum hemorrhage rate in metronidazole＋ceftriaxone group were lower than single-use ceftriaxone group[（1.14±0.51） d vs （2.35±0.37） d],[（38.75±3.16） s vs （46.61±4.27） s],[（12.59±2.52） s vs （17.63±2.75） s],[10.34% vs 17.24%]（P〈0.05）.The case of neonatal pneumonia,neonatal respiratory distress syndrome,neonatal jaundice and Apgar 〈7 of metronidazole＋ceftriaxone group were less than single-use ceftriaxone group（P〈0.05）.The number of chills,convulsions,paralytic ileus and uterine involution were lower than single-use ceftriaxone group（P〈0.05）.Conclusion The drug combination can significantly lower the incidence of acute chorioamnionitis and improve the prognosis.
出处
《医学综述》
2014年第5期932-933,共2页
Medical Recapitulate
关键词
急性绒毛膜羊膜炎
抗生素
联合用药
并发症
Acute chorioamnionitis
Antibiotic
Drug combination
Complications
