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绒毛膜羊膜炎患者血清IL-6、IL-8、MMP-9水平变化及意义 被引量：6

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摘要 目的观察绒毛膜羊膜炎患者血清、羊水中IL-6、IL-8和基质金属蛋白酶-9(MMP-9)水平的变化,并探讨其临床意义。方法采用ELISA法对78例胎膜早破孕妇(研究组)血清和羊水中的IL-6、IL-8、MMP-9进行检测,以50例正常孕妇作对照组,产后研究组取胎膜组织做病理检查。结果研究组中53例病理检查确诊为绒毛膜羊膜炎,其血清和羊水中IL-6、IL-8、MMP-9水平均明显高于25例非绒毛膜羊膜炎患者和对照组(P均<0.05);绒毛膜羊膜炎患者血清和羊水IL-6、IL-8、MMP-9水平呈正相关(r分别0.34、0.41、0.39,P<0.05)。结论孕妇血清和羊水中IL-6、IL-8、MMP-9水平升高,可作为诊断绒毛膜羊膜炎的重要指标。
作者 郎会荣 顾英
机构地区 清河县人民医院
出处 《山东医药》 CAS 北大核心 2010年第26期47-48,共2页 Shandong Medical Journal
关键词 白细胞介素 基质金属蛋白酶 妊娠并发症 绒毛膜羊膜炎 胎膜早破
分类号 R714.25 [医药卫生—妇产科学] R714.43 [医药卫生—妇产科学]
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共引文献49

同被引文献58

  • 1程明刚,郝艳华,陈文萍,黄晓东,梁小勤.血清白细胞介素6、C-反应蛋白测定对早产亚临床绒毛膜羊膜炎的诊断价值[J].现代医院,2004,4(10):21-22. 被引量：2
  • 2李庆军,黄引平.Toll样受体的研究进展[J].新乡医学院学报,2005,22(2):167-170. 被引量：3
  • 3曹耀辉.胎膜早破合并绒毛膜羊膜炎患者胎盘组织中TLR2的表达变化及意义[J].山东医药,2010,50(50):93-94. 被引量：7
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引证文献6

二级引证文献24

山东医药
2010年 第26期

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