摘要
目的观察重组人表皮生长因子外用溶液（金因肽）联合维生素B12防治鼻咽癌急性放射性皮肤损伤的效果。方法将2011年10月至2013年2月在我科治疗的100例鼻咽癌患者,随机分为两组,两组患者在接受放射治疗时,实验组从放疗第1天开始每次放疗后将金因肽外喷于患者照射野皮肤,2小时后增加维生素B1210~20 mg局部外涂,3次/天,出现皮肤损伤后将维生素B12注射液用无菌纱布蘸湿后覆盖于皮炎处;对照组从放疗第1天开始只给予常规皮肤护理。结果实验组发生放射性皮肤损伤的程度明显低于对照组,发生放射性皮肤损伤的时间也较对照组推后,两组比较有显著性差异（P〈0.001）。结论金因肽联合维生素B12的方法治疗或预防性应用于鼻咽癌放疗患者的放射野皮肤能明显减轻放射性皮肤损伤发生的程度,特别能降低Ⅲ级和Ⅳ级放射性皮肤损伤的发生率,有效推迟放射皮肤损伤的发生时间。
Objective Observe the clinical efficacy of Genetimecombined with vitamin B12 on acute radioactive skin damage for nasopharyngeal carcinoma patients. Methods Totally 100 nasopharyngeal carcinoma（ NPC） patientswere included in this study. They were divided into two groups randomly,and received therapy in our hospital during October 2011 and March 2013,all patients in this study undergoing radiotherapy. Patients in experimental group were treated with Genetime and Vitamin B12（ at the dose of 10-20mg,3 time / day） while the patients in control group received routine skin care. Results The occurrence rateof radioactive skin damage in treatment group was significantly lower than control group,and the damage appeared later. Difference between the two groups wasstatistically significant（ P 0. 001）. Conclusions Genetime combined with vitamin B12 was effective for radioactive skin damage,not only slight the damage extent,but also delay the occurrence of damage.
出处
《齐齐哈尔医学院学报》
2014年第3期447-448,共2页
Journal of Qiqihar Medical University
关键词
鼻咽癌
放射治疗
金因肽
维生素B
12
放射性皮肤损伤
预防和治疗
Nasopharyngeal neoplasms/radiotherapy
Recombinat Human Epidermal Growth Factor
Vitamin B12
Radiation-induced skin damage / prevention and treatment
Efficacy
