摘要
目的 观察左洛复对急性冠脉综合征（ACS）PCI术后合并抑郁患者抗抑郁治疗的疗效及对低密度脂蛋白（LDL）、高敏C反应蛋白（hs-C RP）的影响.方法 对150例确诊为急性冠脉综合征的患者行PCI术治疗,术后筛选出伴有抑郁症的患者并通过汉密尔顿（HAMD）抑郁量表进行评分.将其随机分成两组,分别给予心理治疗和左洛复治疗.2个月后对比两组LDL、hs-CRP水平,再次利用HAMD抑郁量表进行评分,根据评分减分率判断疗效.结果 与对照组相比,左洛复治疗组2个月后低密度脂蛋白、hs-CRP水平低于对照组,左洛复对抑郁治疗效果明显高于对照组,差异具统计学意义.结论 左洛复抗抑郁治疗及对冠心病患者预后优于心理治疗.
Objective To explore the efficacy of Zoloft in treatment of depression to the acute coronary syndrome （ACS） patients after percutaneous coronary intervention（PCI） and the effects on low density lipoprotein cholesterol （LDL）, high-sensitivity C-reactive protein （hs-CRP） level. Methods 150 patients were given PCI treatments who diagnosed with acute coronary syndrome, and then depressed patients were screened out and given Hamilton depression rating scale （HAMD） marks. Those patients were divided into two groups randomly and given them psychotherapy and Zoloft treatment respectively. Two months later, compared the two sets levels about LDL, hs-CRP, made use of Hamilton depression rating scale once more to give these patients marks, the curative effect was judged according to the score points. Results Two months later ,compared with control group, Zoloft for treat- ment group had lower level about LDL, hs-CRP. The curative effect of Zoloft for depression treatment was better obviously than the control group. The difference was statistically significant. Conclusion The curative effect of Zoloft in treatment of depression and the prognosis in patients with coronary heart disease（CHD） is better than that of psychotherapy.
出处
《中国心血管病研究》
CAS
2014年第2期174-177,共4页
Chinese Journal of Cardiovascular Research
基金
青岛市卫生科技发展基金项目（项目编号：2010-WSZD025）
