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老年女性冠心病危险因素和冠状动脉病变特点临床研究 被引量:34

Clinical study of risk factors and coronary angiographic findings in elderly female patients with coronary heart disease
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摘要 目的探讨老年女性冠心病患者相关危险因素和冠状动脉病变特点。方法人选2003年4月至2012年5月在我科行Judkins法冠状动脉造影的连续2017例患者,根据年龄、性别及冠状动脉造影结果将其分为老年女性冠心病组(年龄≥60岁,冠状动脉狭窄程度≥50%)760例、老年女性对照组(年龄≥60岁)475例、青中年女性冠心病组(年龄〈60岁,冠状动脉狭窄程度≥50%)97例、老年男性冠心病组(年龄≥60岁,冠状动脉狭窄程度≥50%)685例。分析老年女性冠。tk,病患者临床相关危险因素及冠状动脉病变特点。结果老年女性冠心病组与老年女性对照组比较,收缩压(154.0±28.8)与(146.9±27.2)mmHg(1mmHg一0.133kPa)、空腹血糖(6.5±2.4)与(6.1±1.7)mmol/I。、糖化血红蛋白(6.5±1.3)与(6.2±0.9)%、血清尿酸(312.5---t-104.7)与(282.5土84.5)“mol/L升高(均P〈o.05);高密度脂蛋白胆固醇(1.3±0.5)与(1.5±0.8)mmol/L降低(P〈0.01)。Logistic回归分析结果显示,与老年女性冠心病独立相关的危险因素依次为高密度脂蛋白胆固醇(OR一2.454,95%CI:1.462~4.121,P〈0.01)、血清尿酸(OR一0.997,95%CI:0.995~0.999,P%0.01)、糖化血红蛋白(OR一0.749,95%CI:0.609~0.921,P〈O.01)。老年女性冠心病组冠状动脉造影结果提示,老年女性冠心病患者以多支病变和双支病变为主,行冠状动脉内支架置人术的比例高于青中年女性冠心病组[48.7%(370例)与34.0%(33例),P〈0.053;但较老年男性冠心病组低(48.7%(370例)与55.6%(381例),P〈0.053。结论高密度脂蛋白胆固醇、糖化血红蛋白、血清尿酸是老年女性冠心病发病的独立危险因素,老年女性冠心病患者以多支病变和双支病变为主,冠状动脉病变累及范围广、程度重。 Objective To investigate the risk factors and coronary angiographic findings in elderly female patients with coronary heart disease (CHD). Methods A total of 2017 consecutive patients underwent coronary angiography for enrolled in this study from April 2003 to May 2012. Clinica and angiographic factors were compared among four groups of 760 elderly female CHD patients, 475 elderiy female non CHD patients, 97 young female CHD patients and 685 elderly male CHD patients. Results The levels of systolic blood pressure (SBP, (154.0 ~ 28.8) vs. (146.9 ~ 27.2) mm Hg,1 mm Hg=0.133 kPa], fasting blood glucose [FBG, (6.5_+2.4) vs. (6.1~l. 7) mmol/L~, hemoglobinAlc ~HbAlc, (6.5_--4-1.3) vs. (6.2+_0.9)~3 and uric acid [UA, (312.5~ 104.7) vs. (282.5 +_ 84.5)/~mol/L3 were significantly higher, while high density lipoprotein cholesterol [HDL-C, (1.3~0.5) vs. (1.5~0.8)mmol/L]was significantly lower, in elderly female CHD patients than in elderly female non-CHD patients (all P-(0.05). Multiple logistic regression analysis demonstrated that HDL-C(OR = 2. 454,95 % CI: 1. 462 ~ 4. 121 ), UA (OR = 0. 997,95 % CI: 0. 995~0. 999) and HbAlc(OR=0.749,95%CI:0.609~0.921, P〈0.01)were dependently risk factors for elderly female CHD patients (all P〈0.05). (3)Coronary angiography indicated that the great majority of elderly female CHD patients got double or triple vessel lesion, and had a higherproportion of PCI than that of elderly female non-CHD group (48.7% (370 cases)vs. 34.0G (33 cases), P-Q0. 051, while it had a lower rate compared with the elderly male CHD patients(48.7 G (370 cases)vs. 55.6G(381 cases), P'~0.05~. Conclusions The risk factors of HDL-C, HbAlc and UA are independently correlated with elderly female CHD patients. Diffuse and severe lesions were more common in elderly female CHD patients than age-matched non-CHD control group.
出处 《中华老年医学杂志》 CAS CSCD 北大核心 2013年第10期1076-1079,共4页 Chinese Journal of Geriatrics
关键词 冠心病 危险因素 Coronary disease Risk factors
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