摘要
目的 探讨血管内皮细胞生长因子 (VEGF)和血管生成与胃癌发展的关系。方法 应用免疫组织化学技术 ,检测 42例胃癌组织VEGF蛋白表达和微血管密度 (MVD) ,分析VEGF和MVD及其与胃癌各临床病理指标间关系。结果 VEGF阳性者MVD值显著高于阴性者 (P <0 .0 1) ,VEGF表达和MVD与肿瘤大小、浸润深度、淋巴结转移密切相关 (皆P <0 .0 5 ) ,与肿瘤分化无关 (P >0 .0 5 )。结论 VEGF与胃癌的血管生成密切相关 ,对胃癌的生长和浸润转移有促进作用 ,VEGF或MVD可作为反映胃癌生物学行为的指标之一。
Objective To investigate the relationshop of vascular endothelial growth factor (VEGF) and angiogenesis to the progress of gastric carcinoma (GC).Methods VEGF protein expression and microvessel density (MVD) in 42 cases of human GC were examined by use of immunohistochemical staining.MVD and VEGF expression was analysed together with their relation to clinicopathologic factors.Results MVD was significantly higher in VEGF-positive GC than that in VEGF-negative GC( P <0.01).MVD and VEGF positively correlated with tumor size ( P <0.05),tumor invasion ( P <0.05) and lymph node metastasis ( P <0.05),but their relation to the tumor differentiation was not significant.Conclusion VEGF is highly related to angiogenesis of GC and promotes growth,invasion and metastasis of GC.VEGF expression or MVD is one of the predictors for the biological behavior of GC.
出处
《苏州医学院学报》
2001年第1期59-61,共3页
Acta Academiae Medicinae Suzhou
关键词
胃癌
血管内皮生长因子
肿瘤转移
血管生成
gastric carcinoma
vascular endothelial growth factors
angiogenesis
neoplasm metastasis
