摘要
目的 :探讨补气通络方对周围神经损伤的治疗效果 ,揭示其作用机理 ,为临床用药提供新的方法和途径。方法 :实验通过清洁级 Wistar大鼠 4 8只 ,行右坐骨神经横形切断后即刻原位吻合术造模 ,制成神经损伤模型 ,造模成功后随机分成 4组 ,每组 1 2只。用补气通络胶囊剂和注射剂治疗作 2个观察组 ,设立两个同期对照组 :维生素 B1 +B6的阳性对照组和空白对照组 ,经过造模后 4、8、1 2周 ,每组随机抽取 4只大鼠 ,取其双侧小腿三头肌称量湿重 ,以肌重及恢复程度作为观测指标 ,判断神经的修复情况。结果 :补气通络方两个治疗组的小腿三头肌湿重及其恢复率比维生素 B1 +B6 组恢复快 (P<0 .0 5) ;比空白组差异非常显著 (P<0 .0 1 ) ;维生素 B1 +B6 组的恢复也明显快于空白组 (P<0 .0 5)。结论 :补气通络方对周围神经损伤后的恢复有促进作用 ,有临床开发利用价值。
Purpose:To study the effect and mechanism of Buqi Tongluo Prescription a compound TCM drug including capsule and injection on resumption of rats's injured sciatic nerve and to discover some evidences for clinical treatment on peripheral nerve injury.Methods:48 clean Wistar rats models were made after all rats' right sciatic nerves were cut and then repaired with technique of neurorrhaphy.Then all injured rats were divided randomly into 4 groups and there were 12 rats in each group.All rats divided into Ⅰ group were treated with Buqi Tongluo Capsule,Ⅱ group with Buqi Tongluo Injection,Ⅲ group with Vitamin B 1 & B 6 Capsule,Ⅳ group with no drugs(Ⅳ).When having been treated for 4,8 and 12 weeks,4 rats at one time were picked out randomly from each group and had their wet weight of tricipital muscle (WW 0TM)checked (after being killed) and compared with each other.Results:Both Ⅰ and Ⅱ group rats' WW 0TM were bigger than those of Ⅲ group (P<0.05) and Ⅳ group (P<0.01);and Ⅲ group's WW 0TM bigger than of Ⅳ group's also (P<0.05).Conclusions:Both Buqi Tongluo capsule and injection could facilitate the regeneration of inured peripheral nerve and help injured nerve regain its function.
出处
《中国中医骨伤科杂志》
CAS
2001年第1期10-13,共4页
Chinese Journal of Traditional Medical Traumatology & Orthopedics
基金
广东省中医药管理局资助项目!编号 97197
关键词
补气通络方
从骨神经损伤
小腿三头肌
湿重实验
大鼠
Peripheral nerve injury Buqi Tongluo Prescription Wet weight of tricipital muscle Rat Experiment
