摘要
用钳夹法造成大鼠腓总神经损伤动物模型,灌胃给加味补阳还五汤进行治疗。研究结果显示:用药组再生神经轴索数和损伤神经再生率明显高于对照组P<0.05～0.01;用药组类似正常结构的髓鞘数目多;雪旺氏细胞增殖活跃;失神经肌萎缩程度轻。表明加味补阳还五汤对神经纤维再生、雪旺氏细胞活跃增殖、髓鞘形成及结构完整有明显促进作用。对失神经性肌萎缩有改善作用。为用中医中药治疗神经损伤提供了科学依据。
Animal models of rat common-peroneal-nerve injury were made with forceps～holding method and treated by modified Decoction Invigorating Yang for Recuperation (DIYR) given through the stomach.. The results of the study showed: (1)the axon number of regenerative nerves and the regenerative rate of injured nerves in drug groups were significantly higher than those of the contrls (P<0.05～0.01); (2) the number of paranormal madullary sheaths of the test groups was greater; (3) Schwann's cells in the test groups reproduced more actively; (4) the degree of the muscular atrophy without innervation was slighter. That suggested that DIYR has the significant stimulative effests on nerve fibrae regeneration, Schwann's cells reproduction, madullary sheath formation and structural perfect. The drug can also improve the muscular atrophy without innervation. This study could offer a scientific basis for TCM treatment of nerve injury.
出处
《中医正骨》
1993年第2期6-8,共3页
The Journal of Traditional Chinese Orthopedics and Traumatology
关键词
神经损伤
神经再生
补阳还五汤
PERIPHERAL NERVOUS INJURY/TCM THERAPY EXPETIMENTAL STUDY NERVE REGENERATION/DRUG EFFECTS ANIMALS MODIFIED DECOCTION INVIGORATING YANG FOR RECUPERATION/ PHARMACODYNAMICS
