摘要
目的探讨血小板相关参数和血栓弹力图各指标与糖尿病血管并发症发生、发展的关系,以期尽早发现糖尿病血管并发症高危人群或早期患者。方法根据世界卫生组织关于糖尿病的诊断标准,选取268例患者和80例退休体检者(正常对照组)作为研究对象。将268例患者分为A组HbA1c<6.2%且无血管并发症者;B组HbA1c>6.5%且无血管并发症者和C组HbA1c>8.0%且有血管并发症者。采用西门子公司ADVIA2120全自动血液分析仪测定血小板平均体积(MPV)、血小板分布宽度(PDW)、大血小板(L-PLT)、平均血小板内容物含量(MPM)和平均血小板内容物浓度(MPC)等血小板参数;用TEG@5000凝血分析仪做血栓弹力图分析,检测R值、K值、Angle角和MA值并进行统计学分析。结果 B组L-PLT及C组血小板各参数与正常对照组比较差异有统计学意义(P<0.05)。B组R值、K值、Angle角及C组R值、K值、Angle角、MA值与正常对照组比较差异有统计学意义(P<0.05)。结论血小板相关参数和血栓弹力图检测对帮助糖尿病血管病变的临床诊断,治疗指导和病情监测有重要的意义;血栓弹力图在早期发现糖尿病血管病变患者上比血小板相关参数检测更敏感。
Objective To investigate the relationship between the relevant platelet parameters and the thromboelastographic in-dexes with the the occurrence and development of diabetic vascular complications so as to early find the high-risk group of vascular complications or early patients .Methods According to the WHO diagnostic criteria for diabetes ,268 patients with diabetes and 80 retired people with the physical examination （normal control group） were selected as the research subjects .268 cases were divided into the group A（HbA1c ＆lt;6 .2% without vascular complications） the group B（HbA1c ＆gt;6 .5% without vascular complications） and the group C（HbA1c ＆gt;8 .0% with vascular complications ） .The Siemens ADVIA2120 fully automatic blood analyzer was adopt-ed to detect the platelet parameters of mean platelet volume （MPV） ,platelet distribution width（PDW） ,large-platelet（L-PLT） , MPM and mean platelet concentration（MPC）;The TEG@ 5000 coagulation analyzer was adopted to perform the thromboelastogra-phy for detecting the values of R ,K ,Angle A and MA .All obtained data were statistically analyzed .Results L-PLT in the group B and the platelet parameters in the group C had statistical differences compared with the normal control group （P＆lt;0 .05） .The val-ues of R ,K ,Angle A in the group B and the values of R ,K ,Angle A and Ma in the group C had statistical differences compared with the normal control group （P＆lt;0 .05） .Conclusion Relevant platelet parameters and the thrombelastogram detection have the important significance to help to the clinical diagnosis of diabetic angiopathy ,guide the treatment and the condition monitoring ;the thrombelastogram is more sensitive than the detection of the relevant platelet parameters in early finding the patients with diabetic angiopathy .
出处
《国际检验医学杂志》
CAS
2014年第5期574-575,共2页
International Journal of Laboratory Medicine
关键词
糖尿病
血小板
血栓弹力描记术
diabetes mellitus
blood platelets
thrombelastography
