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右美托咪定在老年患者全麻中减少副反应的临床观察 被引量:6

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摘要 目的观察右旋美托咪啶用于老年患者(年龄≥65岁[1])胃癌手术麻醉的临床研究。方法选择80例美国麻醉医师协会评级(ASA)Ⅰ~Ⅱ级择期胃癌手术老年患者,随机分为生理盐水对照组(A组)和右旋美托咪啶组(B组)(n=40),麻醉诱导前10分钟分别静脉注射右旋美托咪啶1μg/kg、生理盐水10ml后,两组麻醉诱导和维持相同。随后持续注射右旋美托咪啶0.4μg/kg·h直至手术结束前30分钟,观察与记录麻醉诱导前(T0)、插管即刻(T1)、拔管后1分钟(T2)、5分钟(T3)、10分钟(T4)的平均动脉压(MAP)、心率(HR)、血氧饱和度(SaO2)、中心静脉压(CVP)、丙泊酚用量、芬太尼用量及不良反应。结果 T0、T1、T2、T3、T4A组与B组比较,MAP明显下降、HR明显减慢(P<0.05),丙泊酚和芬太尼用药量B组显著少于A组(P<0.05)。B组术后咽喉疼痛、呛咳躁动发生率也明显低于A组(P<0.05)。结论右旋美托咪啶可减轻老年患者胃癌手术全身麻醉气管插管与拔管的心血管反应,减少麻醉药用量,减少胃癌患者术后咽喉疼痛、呛咳躁动等副反应的发生率。
作者 朱轶 吕杰
出处 《浙江创伤外科》 2014年第1期155-156,共2页 Zhejiang Journal of Traumatic Surgery
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