摘要
目的探讨辛伐他汀对急性心肌梗死(AMI)患者炎症水平和内皮功能的影响。方法将我院2010年6月到2012年6月收治的95例AMI患者分为对照组和观察组,对照组给予常规治疗,观察组在对照组治疗基础上给予口服辛伐他汀治疗,分别对对照组和观察组1个月后炎症因子(IL-6、TNF-α、sCD40L、MMP-9、CRP)和内皮功能(vWF、NO、ET-1)进行分析。结果对照组和观察组治疗后IL-6、TNF-α、sCD40L、MMP-9、CRP水平较治疗前明显下降,差异具有统计学意义(P<0.05)。治疗后观察组L-6、TNF-α、sCD40L、MMP-9、CRP水平较对照组明显下降,差异有统计学意义(P<0.05)。对照组治疗前后vWF、NO、ET-1无统计学意义(P>0.05)。观察组治疗后vWF、NO、ET-1水平较治疗前明显降低,差异具有统计学意义(P<0.05)。结论辛伐他汀治可显著改善AMI患者炎症和血管内皮功能。
Objective To explore impact of simvastatin on inflammation and endothelial function in patients with acute myocardial infarction （AMI）. Methods 95 patients with AMI from June 2010 to June 2012 were divided randomly into control group and observe group. Patients in the control group were treated with routine therapy. Patients in the observe group were treated with simvastatin on the basis of routine thera- py. The inflammation （ IL-6, TNF- ct, sCD40L, MMP-9, CRP） and endothelial function （ vWF, NO, ET- 1 ） were estimated in control group and observe group. Results IL-6,TNF-α,sCD40L,MMP-9 and CRP level in the control and observe group after treatment significantly decreased than that before treatment （ P 〈 0.05 ）. After treatment,IL-6,TNF-α, sCD40L,MMP-9 and CRP level in the observe group significantly reduced than that in the control group （ P 〈 0.05 ）. vWF, NO, ET- 1 level in the control group had no significantly difference be- fore and after treatment （P 〉 0.05 ）. After treatment, vWF, NO, ET- 1 level in the observe group significantly improved than that before treatment and control group （ P 〈 0.05 ）. Conclusion simvastatin can significantly improve inflammation and endothelial function in patients with AMI.
出处
《血栓与止血学》
2014年第2期65-67,共3页
Chinese Journal of Thrombosis and Hemostasis
关键词
辛伐他汀
急性心肌梗死
炎症因子
内皮功能
Simvastatin
Acute myocardial infarction
Inflammation
Endothelial function
