摘要
目的探讨布拉氏酵母菌散对轮状病毒肠炎患儿血清白介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)水平的影响及疗效观察。方法选取轮状病毒肠炎患儿84例,随机分为两组(观察组42例和对照组42例)。两组患儿均予以调整饮食、静脉及口服补液、抗病毒及纠正水电解质及酸碱平衡紊乱等常规治疗。观察组患儿加用布拉氏酵母菌散剂治疗,其中<12个月,0.125 g/次,1次/d;≥12个月,0.25 g/次,2次/d。对照组患儿除不予以布拉氏酵母菌散剂治疗,余治疗药物基本同观察组。治疗3 d后,观察两组患儿治疗前后血清细胞因子IL-6和TNF-α水平,并探讨其疗效及不良反应情况。结果治疗3 d后,两组患儿血清IL-6和TNF-α水平均比治疗前明显下降(P<0.05或P<0.01),且观察组较对照组下降更明显(P<0.05);同时观察组患儿的临床总有效率(95.24%)明显好于对照组(78.57%)(χ2=5.13,P<0.05),两组患儿治疗期间无明显的药物不良反应发生。结论布拉氏酵母菌散治疗轮状病毒肠炎患儿疗效及安全性均较好,能降低血清细胞因子IL-6和TNF-α表达水平,抑制炎症及免疫反应过程。
Objective To explore the influence and curative effect of Saccharomyces boulardii powder on the serum levels of Interleukin-6 （IL-6） and tumor necrosis factor-α in children with rotavirus enteritis. Methods 84 chil- dren with rotavirus enteritis were selected and divided into observation group and control group at random, with 42 cases in each group. The two groups were given routine medical treatments such as diet adjustment, intravenous in- fusion and oral rehydration, anti-virus therapy, and adjustment of water electrolyte and acid-base balance etc. The children in observation group were additionally given saccharomyces boulardii powder, 0.25 g per time once a day within 12 months, and 0.5 g per time twice a day after 12 months. After 3 days＇ medical treatment, the serum lev- els of IL-6 and TNF-α in the two groups before and after medical treatment were compared, and the curative effect and adverse reactions were discussed. Results After 3 days＇ medical treatment, the serum levels of IL-6 and TNF-α in both groups obviously declined on average （ P 〈 0. 05 or P 〈 0.01 ）, and the declining rate in observation group was much higher than that in control group （ P 〈 0.05 ）. Meanwhile, the total clinical efficiency in observa- tion group （95.24%） was much higher than that in control group （78.57%） （X2 = 5. 13, P 〈 0.05 ）. No obvious drug adverse reaction appeared in the two groups during the treatment. Conclusion Saccharomyees boulardii pow- der has favorable curative effect and safety in children with rotavirus enteritis, which can reduce the serum levels of cell factors IL-6 and TNF-α and inhibit the inflammatory and immunity reaction process.
出处
《中国微生态学杂志》
CAS
CSCD
2014年第2期181-183,187,共4页
Chinese Journal of Microecology
