摘要
目的评价血清中白介素-6（IL-6）检测对于早期诊断新生儿败血症的价值。方法ELISA法检测对例血培养阳性的败血症新生地急性期血清IL－6浓度，同时检测C-反应蛋白（CRP）、WBC、中性粒细胞计数（PMN）以及杆状核中性粒细胞（I）与中性粒细胞总数（T）之比，并评价各项指标的临床诊断价值。结果IL－6单独诊断时可靠性最高，其敏感性、特异性、阳性预测值（PPV）、阴性预测值（NPV）、约登指数分别为85％、95％、炒叽、86％及0．80，IL-6结合CRP诊断的准确性明显优于经典的评价指标（CRP、WBC、PMN、I／T）。结论IL－6结合CRP可能是早期诊断新生儿败血症的有价值的参数。
Objective To assess the value of interleukin-6 (IL-6) in eary diagnosis of newborns with sepsis. MetkodsSerum IL-6 levels of 37 neonates with positive blood culture sepsis were detected by EUSA and C-reachve protein (CRP,white blood cells (WBC), polymorPhonuclear (PMN), the ratio of immature neutrophils and total neutrophils(I/T)were measuredin acute phase. Results When indices above were judged independently,the reliability of IL-6 was highest with its sensitiv-ity,specilicity, positive predictive value (PPV), negative predictive value (NPV) and Yauden,s index being 85%,95%,94%,86%and 0.80 respechvely. While united tests were used, diagnositic accuracy of IL-6 combining CRP was superior to clas-sical indices (CRP, WBC, PMN, I/T ).Conclusion The combination of IL-6 and CRP seems to be a valuable parameter inthe eary diagnosis of neonatal sepsis.
出处
《中国实验诊断学》
1999年第5期206-208,共3页
Chinese Journal of Laboratory Diagnosis
