摘要
目的探讨原发性输卵管癌的临床特征及诊断。方法对中国医科大学附属盛京医院1996年10月到2010年9月收治并经手术及病理诊断的107例原发性输卵管癌病例进行回顾性分析。结果患者平均年龄54．9岁，绝经者占83％（89例）；最常见的临床表现依次为盆腔肿物39．3％（42例）、下腹部胀痛36．4％（39例）、阴道排液35．5％（38例）、阴道不规则流血31．8％（34例）。107例中65例（60．7％）行肿瘤细胞减灭术，96例（89．7％）行术后化疗；组织学类型：以浆液性腺癌50例（46．7％）及腺癌47例（43．9％）为主。细胞分化：高分化7例（6．5％）、中-低分化100例（93．5％）。FIGO分期：Ⅰ-Ⅱ期39例（36．4％），Ⅲ～Ⅳ期68例（63．6％）。107例中失访25例，随访率76．6％。3年生存率Ⅰ、Ⅱ、Ⅲ-Ⅳ期分别为100％、89．4％、51．2％。总生存期（OS）Ⅰ、Ⅱ、Ⅲ和Ⅳ期分别为6．5、5．8、3．5、0．6年。无瘤生存期（PFS）：Ⅰ、Ⅱ、Ⅲ-Ⅳ期分别为4．03、3．7、1．4年。107例患者中术后复发58例（54．2％）。结论原发性输卵管癌临床表现多样且缺乏特异性，很少能在术前明确诊断。该病恶性程度高，手术及化疗是主要治疗手段。
Objective To analyze the clinicopathologic features and diagnosis of primary fallopian tube carcinoma （PFTC）. Methods As an experimental method, the retrospective analyze has been chosen in this research . 107 cases with PFTC has been involved in this study ,which has been treated, operated and pathologically diagnosed in Shengjing Hospital , China Medical University between October 1996 and September 2010. Results The mean age of these patients was 54. 9 years . Eighty-nine（ 83% ） were menopausal women. The most common clinical situation was pelvic mass （42 , 39. 3% ）, abdominal pain （39,36.4%）, vaginal discharge （38,35.5%）, vaginal bleeding （34,31.8%）. In 107 cases ,65 （60. 7% ） preformed cytoreductive surgery and 96 （89. 7% ） did chemotherapy treatment after surgery . Histology showed mainly serious adenocarcinoma in 50（46. 7% ）and adenocarcinoma in 47 （43. 9% ）. Cytologic grading was high differentiation in 7（6. 5% ）, moderate to poor differentiation in 100（93.5% ） patients. FIGO stages： 39 （36.4%） patients in stage Ⅰ - Ⅱ , 68（ 63.6% ） in stage Ⅲ- Ⅳ. 107 cases, 25 were lost to follow-up, follow-up rate was 76. 6%. The 3 year overall survival rate was followed by 100% ,89.4% ,51.2%. in stage Ⅰ , Ⅱ,Ⅲ - Ⅳ . Overall survival （OS） was followed by 6. 5,5.8,3.5,0. 6 years in stage Ⅰ , Ⅱ , Ⅲ and Ⅳ. Progression free survival（PFS） in stage Ⅰ ,Ⅱ , Ⅲ Ⅳ respectively are 4. 03,3.7,1.4years. In 107 cases , 58 （ 54. 2% ） recurrence after surgery. Conclusion Primary fallopian tube carcinoma is a rare gynecologic malignancy that has various and nonspecific presentations. Preoperative diagnosis of the disease is extremely rare. Patients are often diagnosed at advanced stages . Surgery and chemotherapy arc main therapy for this disease.
出处
《中国实用妇科与产科杂志》
CAS
CSCD
北大核心
2014年第3期186-188,共3页
Chinese Journal of Practical Gynecology and Obstetrics
