摘要
目的:观察补肺益肾汤治疗肺肾两虚型慢性肺源性心脏病心力衰竭患者的临床疗效及对血浆N末端脑钠肽前体(NT-proBNP)、肺动脉压(PAP)的影响。方法:将50例肺肾两虚型慢性肺心病心力衰竭患者随机分为对照组和治疗组各25例,对照组采用西医常规治疗,治疗组在对照组治疗基础上加服补肺益肾汤加减治疗,两组疗程均为15d。观察比较两组临床疗效及血浆NTproBNP、PAP的变化。结果:总有效率治疗组为92.0%,对照组为84.0%,两组比较,差异有统计学意义(P<0.05);治疗后两组血浆NT-proBNP和PAP水平均明显下降(P<0.05),但治疗组下降程度大于对照组(P<0.05)。结论:补肺益肾汤治疗肺肾两虚型慢性肺心病心力衰竭患者的疗效优于西医常规治疗,可能是通过改善患者的NT-proBNP与PAP而发挥作用的。
Objective ： To observe the clinical efficacy of lung - nourishing and kidney - nourishing decoction inpatients with heart failure due to chronic pulmonary heart disease of lung - kidney deficiency type and its effects on plasma N - terminal pro - brain natriuretic peptide （ NT - proBNP） and pulmonary arterial pressure （PAP）. Meth- ods：Fifty patients with heart failure due to chronic pulmonary heart disease of lung - kidney deficiency type were randomly divided into control group （ n = 25 ） and treatment group （ n = 25 ）. The control group received convention- al Western medicine treatment, while the treatment group received modified lung -nourishing and kidney -nouris- hing decoction in addition to conventional Western medicine treatment. The course of treatment was 15 d in both groups. After treatment, the two groups were compared in terms of response rate as well as plasma NT - proBNP and PAP. Results ： The treatment group had a significantly higher overall response rate than the control group （ 92.0% vs 84. 0% ,P 〈 0. 05 ）. Both groups showed significant decreases in plasma NT - proBNP and PAP after treatment （ P 〈 0.05 ）, but the treatment group had a significantly higher decrease than the control group （ P 〈 O. 05 ）. Conclu- sion ： Lung - nourishing and kidney - nourishing decoction is superior to conventional Western medicine treatment in patients with heart failure induced by chronic pulmonary heart disease of lung - kidney deficiency type, and it exerts effects possibly by decreasing plasma NT- proBNP and PAP in patients.
出处
《湖南中医杂志》
2014年第2期8-10,共3页
Hunan Journal of Traditional Chinese Medicine
基金
湖南省中医药管理局资助项目(编号:2010092)
关键词
慢性肺心病
心力衰竭
中医药疗法
补肺益肾汤
NT-PROBNP
PAP
pulmonary heart disease
heart failure
traditional Chinese medicine treatment
lung - nourishingand kidney- nourishing decoction
N -terminal pro -brain natriuretic peptide
pulmonary arterial pressure
