摘要
目的观察乌拉地尔 (URA)预防高血压病人全麻气管插管期间心血管反应的效果。方法 40例确诊高血压病择期全麻手术病人 ,术前血压控制在 2 1 3/ 13 3kPa以下。随机分成A组 (URA组 ,n =2 0 )和B组 (对照组 ,n =2 0 )。A组于麻醉诱导前 5分钟静注URA 0 5mg/kg,B组静注生理盐水。两组均以芬太尼、安定、维库溴铵和丙泊酚静脉诱导后气管插管。记录诱导前、静注URA后 5分钟、诱导后及插管后 1分钟、3分钟、5分钟SBp、DBp、MAP及HR ,并计算RPP。结果A组静注URA后 5分钟SBp、DBp、及MAP显著下降 (P <0 0 1) ,诱导插管期间SBp、DBp、MAP及RPP无明显变化 ,插管后 1分钟HR显著加快 (P <0 0 5 )。B组诱导后SBp、DBp及MAp显著下降 (P <0 0 1) ;插管后 1分钟、3分钟SBp、DBp、MAP及HR显著高于诱导前 (P <0 0 5 ,P <0 0 1) ,插管后 1分钟、3分钟及 5分钟RPP均显著升高 (P <0 0 1) ,与A组同期比较差异有极显著意义 (P<0 0 1)。结论应用URA能有效预防高血压病人气管插管时的心血管反应。
Objective To observe the effects of urapidil on cardiovascular responses to endotracheal intubation in patients with hypertension. Methods 40 cases whose blood pressures were controlled below 21.3/13.3kpa before operation were randomly divided into group A (urapidil group, n =20) and group B ( control group, n =20 ). Group A was injected I. V. Urapidil 0.5mg/kg and normal saline were injected I. V. in group B before endotracheal intubation. Anesthesia was induced with fentany1, valium, norcurium and propofol. SBp, DBp, MAP, HR and RPP were recorded before induction, 5 min after urapidil administration, during intubation and 1, 3, 5 min after intubation respectively. Results SBp, DBp and MAP in group A 5 min after urapidil administration were significantly decreased ( P <0.01), no significant changes occurred in SBp, DBp, MAP and RPP during intubation and 1, 3, 5, min after intubation. The HR was increased significantly than basic level before induction ( P <0.05). SBp, DBp and MAP after induction in group B were decreased significantly ( P <0.01). SBp, DBp, MAP and HR in 1 and 3 min after intubation were increased significantly ( P <0.05, P <0.01). RPP in 1, 3, 5 min after intubation were higher significantly than baseline, and were significantly higher than A group ( P <0.01). Conclusion The urapidil can prevent of effectively the cardiovascular responses on the endotracheal intubation.
出处
《贵州医药》
CAS
2001年第2期127-129,共3页
Guizhou Medical Journal
