摘要
目的 对照研究 5 6例Ⅳ期消化系统恶性肿瘤的腹腔化疗和全身静脉化疗 ,观察并评价两种治疗方法的近期疗效、远期疗效和毒副反应。 方法 随机分为腹腔化疗组 (腹腔组 ) 35例和静脉化疗组 (对照组 ) 2 1例 ,记录观察近期疗效和毒副反应 ,随访患者并计算生存期。采用Kaplan Meier法估计生存函数 ,Logrank检验两组生存函数的差异。 结果 近期疗效两组相仿 ,毒副反应中恶心呕吐、骨髓抑制症状 ,腹腔组明显低于对照组 ,而腹胀腹痛则腹腔组比对照组严重 ,肝肾功能损害两组差异无显著性 ;腹腔组中位生存期和 1年生存率显著高于对照组。 结论 对Ⅳ期消化系统肿瘤患者进行腹腔内化疗 ,可提高生存质量 ,延长患者生存期。
Objective To evaluate the short term and long term therapeutic effects of intraperitoneal versus intravenous chemotherapy in 56 cases with stage IV gastrointestinal cancer. Methods The patients were randomly divided into two groups:35 cases in the intraperitoneally treated group and 21 cases in the intravenously treated group. The short term effects and side effects were observed. The survival time of the patients was also recorded. The survival function was estimated by Kaplan-Meier method, and the significance test was done by Log rank method. Results There was no significant difference between the two groups in short term effects, and liver and kidney damages. Nausea, vomiting and bone marrow suppression were more severe in the intravenously treated group, while abdominal distension and pain were the major side effects in the intraperitoneally treated group. The median survival time and one year survival rate of patients in the intraperitoneally treated group were higher than those in the intravenously treated group. Conclusion For patients with stage IV gastrointestinal cancer, intraperitoneal administration of chemotherapeutic agents is a better treatment of choice.
出处
《中华肿瘤杂志》
CAS
CSCD
北大核心
2001年第1期67-69,共3页
Chinese Journal of Oncology
关键词
消化系统肿瘤
药物疗法
腹腔内化疗
预后
Digestive system neoplasms/drug therapy
Intraperitoneal chemotherapy
Prognosis
