摘要
恶性疟是一种致死性很高的全球性寄生虫病。由于长期抗疟药的使用,目前恶性疟原虫对主要抗疟药物普遍产生抗药性,青蒿素类药物是在氯喹、奎宁抗药性产生后的主要替代治疗药,也是至今唯一没有出现普遍抗药性的抗疟药。但是,近年不少研究和临床观察发现青蒿素类药物的敏感性正逐渐下降,提示恶性疟原虫对青蒿素及其衍生物的抗药性正在形成。本文就近期青蒿素药抗药性的现状及其机制的研究进展情况进行了综述。
Plasmodium tory of antimalarial drug uses, falciparum is a worldwide parasitic disease that leads to high mortality. Through the long his P. falciparum has become resistant to all major antimalarials. As the leading substitute antima larials following the occurrence of resistance to chloroquine and quinine, artemisinin and its derivatives are the only class of anti- malarials with apparent resistance. Unfortunately, the decrease in sensitivity has already been detected through a lot of research and clinical monitoring. Evidence has accumulated to indicate that P. falciparum are gradually becoming resistant to artemisi- nin and its derivatives. In this review, we summarize the current situation of resistance to artemisinin and its derivatives and the research progress on the resistance mechanism.
出处
《中国人兽共患病学报》
CAS
CSCD
北大核心
2014年第2期195-198,共4页
Chinese Journal of Zoonoses
基金
国家自然科学基金(No.U1202226
81161120421and 31260508)
教育部高等学校博士学科点专项科研基金(No.20125317110001)联合资助~~
