摘要
20世纪80年代以来,我国自主研发的青蒿素类药物作为替代氯喹治疗恶性疟最有效的一线药物之一被全世界恶性疟原虫流行区广泛使用,拯救了数100万计生命。随着长时间的广泛使用,其敏感性呈缓慢下降趋势。研究一种新抗疟药需要历时十几年或几十年的时间,为保护青蒿素类药物,延缓抗性产生与发展,全球科研工作者开展大量研究,并且取得可喜成果。本文对青蒿素类药物的发展和使用,青蒿素类药物敏感性监测和影响因素等进行综述。
Since the 1980s, artemisinin-based drugs have been independently researched and developed in China in place of chloroquine for treatment of falciparum malaria. These drugs are one of the most effective first-line drugs and they are widely used in areas around the world where Plasrnodium falciparurn malaria is endemic to save the lives of millions. Plasrnodium falciparum tends to gradually lose its sensitivity to drugs as they are widely used over a long period of time. Research on new antimalarial drugs to preserve the effectiveness of artemisinin-based drugs and delay the development of resistance will take a decade or even several decades. Researchers around the world are conducting numerous studies that have yielded promising results. This paper reviews the development and use of artemisinin-based drugs, monitoring of sensitivity to artemisinin-based drugs, and factors influencing that sensitivity.
出处
《中国病原生物学杂志》
CSCD
北大核心
2014年第1期I0001-I0003,共3页
Journal of Pathogen Biology
关键词
恶性疟
青蒿素类药物
敏感性
监测
综述
Plasmodium falciparum
artemisinin-based drugs
sensitivity
monitoring
review
