摘要
目的观察 5Hz和 2 0Hz磁场对脑缺血损害的影响。方法采用左侧颈总动脉阻断致大鼠急性脑缺血 ,缺血后给予 5Hz和 2 0Hz的磁场刺激 3h或 5h。观察脑细胞的缺血性病理变化。结果锥体细胞和星形胶质细胞表现出不同的缺血性病理变化 ;对锥体细胞的缺血性损害 5Hz组轻于对照组和 2 0Hz组 ,而对星形胶质细胞则表现为 5Hz组的缺血性损害程度重于对照组和 2 0Hz组 ;2 0Hz组的缺血性损害程度与对照组相似。结论不同频率的磁场对大鼠脑急性缺血性损害有不同的影响 ,磁场的频率效应可能与磁场作用机制及细胞的不同特性有关。
Objective To compare the effects of 5 Hz and 20 Hz magnetic field on cerebral ishemia in rats. Method After cerebral ischemia was produced by ligation of the left general carotid artery,rats were stimulated by magnetic fields of 5 Hz and 20 Hz respectively and pathological changes in neurocytes were observed. Result (1) Different pathological changes were observed in different cells;(2)The extent of damage of pyramidal cells was milder in 5 Hz magnetic field groups than those in the control group ,and the effect was not remarkable in the 20 Hz group;(3)The effect on astroglia was worse in 5 Hz group than that in control and 20 Hz group. Conclusion Magnetic field stimulation influences cerebral ischemic reaction with frequency dependency.
出处
《航天医学与医学工程》
CAS
CSCD
北大核心
2001年第1期40-44,共5页
Space Medicine & Medical Engineering
关键词
磁场
磁效应
脑缺血
比较研究
magnetic field
magnetic effects
cerebral ischemia
rats
