摘要
目的 :建立大鼠心肌肥厚—心力衰竭模型 ,深入心衰机制的研究。方法 :缩窄幼年 Wistar大鼠升主动脉 ,缓慢增加左心室压力后负荷 ,建立心肌肥厚—心力衰竭模型 ,并随机分为升主动脉缩窄组和同期假手术组 ,观察术后不同时间大鼠临床表现、尾动脉血压、体重、器官重量、心脏超声和血液动力学参数的变化。结果 :手术成活率87% ,缩窄术后 4周出现心肌肥厚 ,12周明显肥厚 ,2 0周出现失代偿性心力衰竭。结论 :此方法有效且重复性好 ,可较理想地模拟慢性压力后负荷心肌肥厚—心力衰竭的转变 。
Objective:Our purpose was to establish an ideal chronic pressure afterload heart failure rat model which has the transition from cardiac hypertrophy to heart failure. Methods: Chronic pressure afterload heart failure rat model was induced by gradually constricting the ascending aorta of young rats. Young rats were randomly divided into 2 groups: the constricted and sham operated groups. Clinical manifestation, tail cuff blood pressure, organ weight, and hemodynamic data were observed at various time after operation. Results: The overall survival rate was 87%. Tail cuff pressure began to increase in 4 weeks after operation. Left ventricular hypertrophy appeared in 12 weeks and heart failure in 5 months. Conclusion:It's a practical and reproducible model of cardiac hypertrophy that progresses to chronic heart failure.
出处
《中国医科大学学报》
CAS
CSCD
北大核心
2001年第1期9-11,共3页
Journal of China Medical University
