期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

一种新前炎症因子-Cyr61参与类风湿关节炎发病的重要启示 被引量：3

原文传递
导出
摘要 基质蛋白是一大类由组织细胞分泌的蛋白分子,广泛参与多种生理活动,在炎症和组织损伤中也具重要作用[1-2].在自身免疫病中,目前已经发现许多基质蛋白直接介导组织损伤,如类风湿关节炎（rheumatoid arthritis,RA）的滑膜细胞产生的基质金属蛋白酶能直接导致RA患者软骨和骨破坏[2]、骨桥蛋白可以介导单核巨噬细胞、T细胞活化从而加重炎症[1]等等.这些发现均表明炎症部位的组织细胞和基质蛋白对于炎症的过程十分重要,它们能与炎症环境中免疫细胞相互作用,共同促进炎症发展,导致组织损伤和疾病,是潜在的干预靶点.
作者 李宁丽
机构地区 上海交通大学医学院
出处 《中国医师杂志》 CAS 2014年第1期47-50,共4页 Journal of Chinese Physician
关键词 细胞因子类 代谢 关节炎 类风湿
分类号 R593.22 [医药卫生—内科学]
  • 相关文献

参考文献25

  • 1Xu G,Nie H,Li N. Role of osteopontin in amplification and perpetuation of rheumatoid synovitis[J].{H}Journal of Clinical Investigation,2005,(04):1060-1067.
  • 2Manetti M,Guiducci S,Romano E. Increased serum levels and tissue expression of matrix metalloproteinase-12 in patients with systemic sclerosis:correlation with severity of skin and pulmonary fibrosis and vascular damage[J].{H}ANNALS OF THE RHEUMATIC DISEASES,2012,(06):1064-1072.
  • 3Holbourn KP,Acharya KR,Perbal B. The CCN family of proteins:structure-function relationships[J].{H}Trends in Biochemical Sciences,2008,(10):461-473.
  • 4Jun JI,Lau LF. The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing[J].{H}Nature Cell Biology,2010,(07):676-685.
  • 5Lau LF,Nathans D. Identification of a set of genes expressed during the G0/G1 transition of cultured mouse cells[J].{H}EMBO Journal,1985,(12):3145-3151.
  • 6Lau LF,Lam SC. The CCN family of angiogenic regulators:the integrin connection[J].{H}Experimental Cell Research,1999,(01):44-57.
  • 7O'Brien TP,Yang GP,Sanders L. Expression of cyr61,a growth factor-inducible immediate-early gene[J].{H}Molecular and Cellular Biology,1990,(07):3569-3577.
  • 8Jay P,Bergé-Lefranc JL,Marsollier C. The human growth factor-inducible immediate early gene,CYR61,maps to chromosome 1p[J].{H}ONCOGENE,1997,(14):1753-1757.
  • 9Jun JI,Lau LF. Taking aim at the extracellular matrix:CCN proteins as emerging therapeutic targets[J].{H}Nature Reviews Drug Discovery,2011,(12):945-963.
  • 10Zhang Q,Wu J,Cao Q. A critical role of Cyr61 in interleukin-17-dependent proliferation of fibroblast-like synoviocytes in rheumatoid arthritis[J].{H}ARTHRITIS AND RHEUMATISM,2009,(12):3602-3612.

同被引文献50

  • 1O'Brien TP,Yang GP,Sanders L,et al.Expression of cyr61,a growth factor-inducible immediate-early gene[J].Mol CeU Biol,1990,10:3569-3577.
  • 2Jay P,Berge-Lefranc JL,Marsollier C,et al.The human growth factor-inducible immediate early gene,CYR61,maps to chromosome 1p[J].Oncogene,1997,14:1753-1757.
  • 3Lau LF,Lam SC.The CCN family of angiogenic regulators:the integrin connection[J],Exp Cell Res,1999,248:44-57.
  • 4Lau LF,Nathans D.Identification of a set of genes expressed during the G0/G1 transition of cultured mouse cells[J].EMBO J,1985,4:3145-3151.
  • 5Lobel M,Bauer S,Meisel C,et al.CCN1:a novel inflammation-regulated biphasic immune cell migration modulator[J].Cell Mol Life Sci,2012,69:3101-3113.
  • 6Leu SJ,Chen N,Chen CC,et al.Targeted mutagenesis of the angiogenic protein CCN1(CYR61).Selective inactivation of integrin alpha6betal-heparan sulfate proteoglycan coreceptor-mediated cellular functions[J].J Biol Chem,2004,279:44177-44187.
  • 7Bai T,Chen CC,Lau LF.Matricellular protein CCN1activates a proinflammatory genetic program in murine macrophages[J].J Immunol,2010,184:3223-3232.
  • 8Kok SH,Hou KL,Hong CY,et aL Simvastatin inhibits cytokine-stimulated Cyr61 expression in osteoblastic cells:a therapeutic benefit for arthritis[J].Arthritis Rheum,2011,63:1010-1020.
  • 9Zhang Q,Wu J,Cao Q,et al.A critical role of Cyr61in interleukin-17-dependent proliferation of fibroblastlike synoviocytes in rheumatoid arthritis[J].Arthritis Rheum,2009,60:3602-3612.
  • 10Lin J,Zhou Z,Huo R,et al.Cyr61 induces IL-6production by fibroblast-like synoviocytes promoting Thl7 differentiation in rheumatoid arthritis[J].J Immunol,2012,188:5776-5784.

引证文献3

二级引证文献8

中国医师杂志
2014年 第1期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部