摘要
目的:观察结肠癌组织星形细胞上调基因-1(astrocyte elevated gene-1,AEG-1)的表达情况,并分析AEG-1表达与结肠癌临床病理特征的关系。方法:采用免疫组化EnVision二步法检测63例结肠癌组织和30例正常结肠黏膜AEG-1的表达情况,并分析AEG-1表达与结肠癌临床病理特征的关系。结果:63例结肠癌组织AEG-1阳性表达率为68.25%(43/63),30例正常结肠黏膜AEG-1阳性表达率为26.67%(8/30),结肠癌组织AEG-1阳性表达率明显高于正常结肠黏膜,差异具有统计学意义(χ2=14.192,P<0.01)。结肠癌组织AEG-1的表达与肿瘤的分化程度和分期有关(P<0.05),与性别、年龄、肿瘤大小无关(P>0.05)。结论:AEG-1在结肠癌中表达升高,其异常表达与结肠癌的发生、发展有关。
Objective：To observe the expression of astrocyte elevated gene-1 （AEG-1） in colonic carcinoma and analyze the relationship between AEG-1 and clinicopathological characteristics of colonic carcinoma.Methods：EnVision immunohistochemical method was used to detect the expression of AEG-1 in 63 cases colonic carcinoma and 30 cases normal colonic mucosa;and then the relationship between AEG-1 and clinicopathological characteristics of colonic carcinoma was analyzed.Results：In 63 cases colonic carcinoma, the positive expression rate ofAEG-1 was 68.25%（43/63）;In 30 cases normal colonic mucosa, the positive expression rate of AEG-1 was 26.67%（8/30）;the positive expression rate of AEG-1 in colonic carcinoma was obviously higher than that in normal colonic mucosa （χ2=14.192, P＆lt;0.01）. The expressionofAEG-1incoloniccarcinomawasrelatedtodifferentiateddegreeandTNMstageofcoloniccarcinoma（P＆lt;0.05）;but had no relations with sex, age and tumor size （P＆gt;0.05）. Conclusions：Upregulation of AEG-1 expression in colonic carcinomaiscloselyrelatedwithdevelopmentofcolonic carcinoma.
出处
《承德医学院学报》
2014年第1期19-21,共3页
Journal of Chengde Medical University
